1 results
01/Jan/2011
01/Jan/2011
DOI: 10.1590/S1679-45082011AO1852
ABSTRACT Objective: To assess the long-term impact (minimum of 3 years follow-up) of polymorphisms in cytokine genes in donor:recipient pairs on the results of the transplant. Methods: We compared genetic cytokine polymorphisms and the primary factors of risk for the development of chronic rejection in paired groups of renal transplant patients with and without chronic allograft nephropathy [CAN]. Results: Multivariate analysis indicated that the presence of the high-production TT genotype (codon 10) of the transforming growth factor beta-1 (TGFB1) was […]
Keywords: Chronic renal allograft dysfunction; Donor genotype; Genetic polymorphism; Interferon-gamma; Transforming growth factor beta-1