INTRODUCTION Despite medical advances and numerous efforts to mitigate cognitive decline, aging remains a universal process affecting all individuals.()Cognitive decline complexity in the older population results from the interplay of various aging-related factors, including cellular senescence, epigenetic modifications, and metabolic dysfunction. Brain aging phenotypes, such as vascular dysfunction, inflammation, and lipid dysregulation, further interact with central nervous system processes, leading to morphological, cognitive, and neuropathological changes, ultimately contributing to neurodegenerative diseases.() Dementia, characterized by severe cognitive decline that interferes with […]

ABSTRACT Objective To investigate associations between respiratory capacity, quality of life and cognitive function in elderly individuals. Methods The sample included 386 elderly individuals (232 women). Respiratory capacity assessment was based on maximal expiratory pressure measured at peak expiratory flow. Subjects were classified according to peak expiratory flow values adjusted for sex, age and height of individuals with normal (peak expiratory flow curve 60%) or reduced (peak expiratory flow curve < 60%) respiratory capacity. The World Health Organization Quality of [...]

OBJECTIVE: To evaluate the diagnostic sensitivity, specificity, and agreement of the Dementia Rating Scale with clinical diagnosis of cognitive impairment and to compare its psychometric measures with those from Mini Mental State Examination. METHODS: Eighty-six elders from a long-term care institution were invited to participate in a study, and fifty-eight agreed to participate. The global health assessment protocol applied to these elders contained Mini Mental State Examination and Dementia Rating Scale. Clinical diagnose of cognitive impairment was performed by experts […]