2 results
22/Sep/2025
DOI: 10.31744/einstein_journal/2025AO1421
INTRODUCTION Premature ovarian insufficiency (POI) is a clinical syndrome characterized by oligo/amenorrhea observed in women before the age of 40 years, lasting at least 4 months, with elevated follicle-stimulating hormone (FSH) levels.() Its diagnosis is confirmed by two serum measurements conducted at least 1 month apart that show high FSH levels (>25IU/L) and low estradiol levels.() The condition is caused by varying factors, including genetic, immunological, or metabolic factors; iatrogenic intervention; and environmental toxins. The reason is idiopathic in 90% […]
Keywords: Autoimmunity; Biomarkers; Inflammation; MicroRNAs; Peripheral blood; Primary ovarian insufficiency
06/Nov/2024
DOI: 10.31744/einstein_journal/2024RC1105
ABSTRACT The development of alloantibodies or autoantibodies is a complication observed in sickle cell disease. Autoimmunization occurs in 7.6-12% of chronically or intermittently transfused patients with sickle cell disease; however, the clinical implications of autoAbs are unclear. Few studies have focused on pediatric sickle cell disease and autoimmune hemolytic anemia. Herein, we present the coexistence of sickle cell disease and autoimmune hemolytic anemia in two adolescent patients, focusing on their pathophysiology, diagnosis, clinical management, and outcomes.
Keywords: Adolescent; Anemia,hemolytic,autoimmune; Anemia,sickle cell; Autoantibodies; Autoimmunity