22/Apr/2025
Prevalence of autoimmune diseases in patients with type 1 diabetes: a scoping review
DOI: 10.31744/einstein_journal/2025RW1222
ABSTRACT Objective To evaluate the prevalence of autoimmune diseases in patients with type 1 diabetes mellitus. Methods This scoping review was conducted following the Joanna Briggs Institute guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) tool to ensure methodological rigor. We systematically searched PubMed, Embase, Scopus, Lilacs, and Web of Science databases to identify relevant literature published between 2018 and 2023. Results Twenty-four studies were included, mostly single-center studies from six continents, […]
Keywords: Addison disease; Autoimmune diseases; Celiac disease; Diabetes mellitus, type 1; Thyroiditis, autoimmune
26/Feb/2025
Intravenous immunoglobulin therapy in erythromelalgia management: a case report
DOI: 10.31744/einstein_journal/2025RC1236
ABSTRACT A 49-year-old woman presented with a 16-year history of burning pain, warmth, redness, and edema in both toes, feet, legs and calves. Despite extensive medical testing, including genetic analysis, no specific cause was identified. Initial treatments failed to improve symptoms, leading to impaired quality of life and mental health. Eventually, a six-month course of intravenous immunoglobulin therapy provided complete relief, allowing the patient to resume normal activities. Erythromelalgia is a rare neurovascular condition characterized by pain, warmth, and erythema […]
Keywords: Autoimmune diseases; Erythromelalgia; Immunoglobulins, intravenous; NAV17 Voltage-gated sodium channel; Small fiber neuropathy
22/Jan/2020
Comparison between enzyme-linked immunosorbent assay and indirect immunofluorescence for detection of antineutrophil cytoplasmic antibodies
einstein (São Paulo). 22/Jan/2020;18:eAO5132.
View Article22/Jan/2020
Comparison between enzyme-linked immunosorbent assay and indirect immunofluorescence for detection of antineutrophil cytoplasmic antibodies
DOI: 10.31744/einstein_journal/2020AO5132
ABSTRACT Objective To evaluate the performance of enzyme-linked immunosorbent assay and indirect immunofluorescence methods for the detection of antineutrophil cytoplasmic antibodies in a routine clinical laboratory setting. Methods A total of 227 samples were tested by indirect immunofluorescence and enzyme-linked immunosorbent assay with antigen specificity for antiproteinase 3 and antimyeloperoxidase. The proportions of positive samples were compared by McNemar hypotheses and agreement was described by Cohen’s Kappa coefficient. Results The agreement of the tests was 96.5%, and the Kappa coefficient […]
Keywords: Antibodies, antineutrophil cytoplasmic; Autoantibodies; Autoimmune diseases; Enzyme-linked immunosorbent assay; Fluorescent antibody technique, indirect