Highlights ■ TDF + 3TC + DTG decreases the number of viable stromal vascular cells in subcutaneous adipose tissue. ■ TDF + 3TC + DTG decreases the number of viable stromal vascular cells in visceral adipose tissue. ■ TDF + 3TC + DTG increases leptin and FABP4 expression  in subcutaneous adipose tissue. ABSTRACT Introduction: Several antiretroviral regimens reportedly affect adipose tissue function. While earlier antiretroviral combinations were associated with lipodystrophy, more recent regimens, particularly those containing dolutegravir, have been linked […]

ABSTRACT Introduction The human immunodeficiency virus (HIV) pandemic remains an important issue. In 2020, approximately 37.7 million people were living with the disease and there were more than 680 thousand deaths due to complications linked to the disease. Despite these exorbitant numbers, the introduction of highly active antiretroviral therapy has marked a new era, changing the epidemiological profile of the infection and related pathologies, including neoplasms. Objective We performed a literature review to assess the role of neoplasms in patients […]

Highlights Viral suppression improved after introducing a dolutegravir-based regimen. HIV viral loads <50 copies/mL were lower than expected (<90%). Higher viral suppression was found when antiretroviral therapy adherence/alterations were controlled (per-protocol analysis). Some baseline characteristics can influence the effectiveness of first-line antiretroviral therapy. ABSTRACT Objective To compare viral suppression in treatment-naïve adults starting antiretroviral therapy with dolutegravir (50mg)- and efavirenz (600mg)-based regimens. Methods We analyzed secondary data from Brazilian health information systems of people living with human immunodeficiency virus who […]

ABSTRACT Objective To characterize the epidemiological profile of patients aged 50 years or older diagnosed as HIV/AIDS, in a Specialized Service of the Public Health System. Methods A retrospective cohort study using secondary data from medical records in the period 2014 to 2018. Sociodemographic and clinical characteristics, and features related to treatment adherence were organized in a database. Quantitative variables were expressed as mean (or median) ± standard deviation (or interquartile range), and categorical variables expressed as number and percentage […]