28/Aug/2025
Elderly patients in crisis: unveiling outcomes and management approaches in severe COVID-19 cases – a retrospective analysis from Brazil
einstein (São Paulo). 28/Aug/2025;23:eAO1428.
View Article28/Aug/2025
Elderly patients in crisis: unveiling outcomes and management approaches in severe COVID-19 cases – a retrospective analysis from Brazil
DOI: 10.31744/einstein_journal/2025AO1428
Highlights ■ The elderly had higher severity, more comorbidities, and longer intensive care unit and hospital stays than adults. ■ They required more assistance resources and had higher hospital mortality. ■ Independent mortality predictors: age ≥60, frailty, arrhythmia, transplant, acute kidney injury, vasopressors and extracorporeal membrane oxygenation. ABSTRACT Objective: To analyze the sociodemographic and clinical characteristics, comorbidities, therapeutic resources, and mortality rates of elderly patients with COVID-19 admitted to an intensive care unit. Methods: This retrospective cohort study included patients […]
Keywords: Acute kidney injury; Aged; COVID-19; Critical care outcomes; Hospital mortality; Intensive care units; Length of stay; Mortality
25/Sep/2024
Acute kidney injury in coronavirus disease: a comparative study of the two waves in Brazil
DOI: 10.31744/einstein_journal/2024AO0687
ABSTRACT Highlights Renal involvement was frequent in patients with COVID-19 and related to worse outcomes. Diuretic use, mechanical ventilation, proteinuria, hematuria, age, and creatine phosphokinase and D-dimer levels were risk factors for acute kidney injury. Acute kidney injury, mechanical ventilation, elevated SOFA Score, and elevated ATN-ISS were associated with mortality. The second wave was associated with greater severity; however, the mortality rates were similar between the two periods. This may reflect the effectiveness of vaccines and the constant learning that […]
Keywords: Acute kidney injury; Brazil; Coronavirus infections; COVID-19; Incidence; Mortality; Prognosis; Receptor cross-talk
30/Aug/2023
COVID-19-associated coagulopathy and acute kidney injury in critically ill patients
DOI: 10.31744/einstein_journal/2023AO0119
Highlights 43.4% of the cohort developed acute kidney injury. D-dimer and fibrinogen levels were high in both groups. Rotational thromboelastometry data were similar between groups. Serum levels of antithrombin activity and protein C were lower in patients who developed acute kidney injury. Objective The incidence of thrombotic events and acute kidney injury is high in critically ill patients with COVID-19. We aimed to evaluate and compare the coagulation profiles of patients with COVID-19 developing acute kidney injury versus those who […]
Keywords: Acute kidney injury; Blood coagulation; Coronavirus infections; COVID-19; Intensive care units; SARS-CoV-2; Thrombosis
02/May/2022
Relation between red blood cell distribution width and acute kidney injury in patients with sepsis
einstein (São Paulo). 02/May/2022;20:eAO6828.
View Article02/May/2022
Relation between red blood cell distribution width and acute kidney injury in patients with sepsis
DOI: 10.31744/einstein_journal/2022AO6828
ABSTRACT Objective The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis. Methods This is a retrospective study of 849 critically ill patients with sepsis in intensive care unit. Demographic data, renal function, inflammation, complete blood count, and acid-base parameters were compared between acute kidney injury and non-acute kidney injury groups. Therefore, a multivariate analysis was performed to observe independent predictive factors. Results Comparatively, higher levels of […]
Keywords: Acute kidney injury; Erythrocyte indices; Renal replacement therapy; Sepsis