Flouroquine use and risk of aortic aneurysm and dissection: nationwide cohort study
Using the excellent Swedish medical record system a study analyzed medical charts of all patients treated with fluoroquinone between July 2006 and December 2013. The study reported that within 60 days after fluorquinolone use the ratio of aortic aneurysm and dissection was 1.2 cases/1000 persons compared to 0.7 cases/1000 persons who were amoxicillin users. The size of both samples was impressive: 360,088.00 fluoroquinone users (78 % ciprofloxacin) and 360,088.00 matched ampicillin users . The relative hazard risk for both aortic dissection and aortic aneurysm in fluoroquinolone users was 1.66 % with confidence interval of 1.12% to 2.46%, respectively. The known risk of Achilles tendon rupture was also higher from 15 to 30 days after fluorquinolone use. The authors suggested that possibility of up-regulation of metalloproteinases was related with the finding.
Pasternak B, Inghammar M, Swabstrom H. Flouroquine use and risk of aortic aneurysm and dissection: nationwide cohort study. BMJ. 2018;360:k678. http://doi 10.1136/bmj.k678.