23/jul/2025
Time-Driven Activity-Based Costing (TDABC) applied in a chemotherapy department of a public reference oncology hospital
DOI: 10.31744/einstein_journal/2025GS0679
Highlights ■ Using the Time-Driven Activity-Based Costing method in healthcare services enables resource maximization with better control of processes and financing. ■ The estimated cost of treating a patient per antineoplastic session is R$ 470,35. ■ Such analyses can help establish pricing strategies and identify necessary adjustments to the financing model in oncology. ABSTRACT Objective: To identify the costs pertaining to the preparation and administration process of each chemotherapy treatment session in a public oncology hospital belonging to the Brazilian […]
Palavras-chave: Antineoplásicos; Custos e análise de custo; Quimioterapia; Health care costs; Serviços de Saúde; Oncologia; Micro-costing; Avaliação da tecnologia biomédica; Sistema Único de Saúde
28/abr/2025
Omission of dexamethasone in prophylaxis for highly emetogenic chemotherapy in patients with breast cancer
DOI: 10.31744/einstein_journal/2025AO1124
Highlights ■ Evaluation of a corticosteroid-free antiemetic regimen. ■ Primary endpoint: 46% nausea control. ■ Secondary endpoint: 68% emesis control. ■ Comparable to standard four-drug protocols. ABSTRACT Objective: Chemotherapy-induced nausea and vomiting are highly prevalent adverse events that can lead to poor treatment adherence and a decreased quality of life. To the best of our knowledge, the complete omission of dexamethasone from any regimen for preventing nausea and vomiting has not yet been evaluated. This study aimed to evaluate the […]
Palavras-chave: Antineoplásicos; Neoplasias da mama; Dexametasona; Quimioterapia; Efeitos colaterais e reações adversas relacionados a medicamentos; Nausea; Olanzapine; Vomiting
25/jun/2024
Comprehensive analysis: efficacy of pembrolizumab as an initial therapy for PD-L1 negative NSCLC
DOI: 10.31744/einstein_journal/2024ABS_BTS_STO010
Category: Thoracic Oncology Introduction: Bronchogenic tumors, predominantly non-small cell type (NSCLC), are a global health concern, with adenocarcinomas, their most common subtype, being most often diagnosed at advanced stages, making it essential to develop effective therapeutic strategies, especially for patients with NSCLC who do not express the PD-L1 (Programmed Death-Ligand 1) protein. Two pivotal studies, Keynote-189() and Keynote-407,() presented their combined results in 2023, after a 5-year follow-up,() concluding that the combination of Pembrolizumab and chemotherapy demonstrated substantial improvements in […]
Palavras-chave: Quimioterapia; Imunoterapia; Neoplasias do pulmão; Non-small-cell-lung; PD-L1 protein
05/jul/2022
Effects of glucocorticoids on interstitial glucose concentrations in individuals with hematologic cancer and without known diagnosis of diabetes: a pilot study
einstein (São Paulo). 05/jul/2022;20:eAO8031.
Ver Artigo05/jul/2022
Effects of glucocorticoids on interstitial glucose concentrations in individuals with hematologic cancer and without known diagnosis of diabetes: a pilot study
DOI: 10.31744/einstein_journal/2022AO8031
ABSTRACT Objective To analyze interstitial glucose behavior during glucocorticoid use in non-diabetic patients receiving chemotherapy for hematologic malignancies. Methods Prospective pilot study carried out to assess interstitial glucose levels in 15 non-diabetic individuals with hematologic malignancies who received glucocorticoids in combination with chemotherapy. The FreeStyle Libre flash monitoring system (Abbott Diabetes Care) was used for up to 14 days to measure interstitial glucose. Results Median age and body mass index were 53 (42-61) years and 25 (23-28) kg/m2 respectively. Interstitial […]
Palavras-chave: Glicemia; Diabetes mellitus tipo 2; Quimioterapia; Glucocorticoids; Glucose; Hematologic neoplasms; Hiperglicemia; Linfoma
05/jul/2022
Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy
einstein (São Paulo). 05/jul/2022;20:eMD8044.
Ver Artigo05/jul/2022
Investigation of nerve fibers in the skin by biopsy: technical aspects, indications, and contribution to diagnosis of small-fiber neuropathy
DOI: 10.31744/einstein_journal/2022MD8044
ABSTRACT Skin biopsy with investigation of small-diameter nerve fibers in human epidermis and dermis has been proven to be a useful method for confirming small-fiber neuropathy. In medical practice, small-fiber neuropathy is increasingly recognized as a leading cause of neuropathic pain. It is a prevalent complaint in medical offices, brought by patients often as a “painful burning sensation”. The prevalence of neuropathic pain is high in small-fiber neuropathies of different etiologies, especially in the elderly; 7% of population in this […]
Palavras-chave: Biópsia; Diabetes mellitus tipo 2; Neuropatias diabéticas; Quimioterapia; Fabry disease; HIV; Nerve fibers; Neuralgia, postherpetic; Rheumatic diseases; Pele; Small fiber neuropathy
01/out/2016
Inserção braquial de cateteres venosos totalmente implantáveis para quimioterapia: complicações e avaliação da qualidade de vida em 35 pacientes
DOI: 10.1590/S1679-45082016AO3606
RESUMO Objetivo Avaliar prospectivamente segurança perioperatória, complicações precoces e grau de satisfação de pacientes submetidos ao implante de cateteres centrais de inserção periférica pela veia basílica. Métodos Foram acompanhados prospectivamente e submetidos ao implante de cateteres de longa permanência de inserção periférica, entre novembro de 2013 e junho de 2014, 35 pacientes consecutivos com doença oncológica ativa necessitando de quimioterapia. Os procedimentos foram realizados em centro cirúrgico por uma mesma equipe composta por três cirurgiões vasculares. Os desfechos primários avaliados […]
Palavras-chave: Cateteres de demora/efeitos adversos; Quimioterapia; Satisfação do paciente; Segurança do paciente