Highlights ■ Restrictive ligand density can be pathological. ■ Restrictive ligand density can be neutralized. ■ Restrictive ligand density neutralization may the used to heal or prevent disease. ABSTRACT Objective: This study examined the correlation between immunodominance of the major egg antigen Sm-p40234-246, a robust Th1/Th17 anti-egg CD4 T-cell response, and severe liver immunopathology in experimental murine schistosomiasis. It serves as a platform to analyze how varying degrees of immunodominance affect CD4+ T cell modulation and disease outcomes. Methods: We […]
