Highlights ■ AKT signaling sustains the immune evasion mechanisms in acute myeloid leukemia. ■ AKT inhibition increases the susceptibility of acute myeloid leukemia cells to natural Killer-mediated apoptosis. ■ Partial blockage of AKT signaling promotes the suppression of PDL1 and overexpression of pro-apoptotic genes. ABSTRACT Objective To determine the role of the AKT pathway in the regulating of natural Killer-induced apoptosis of acute myeloid leukemia cells and to characterize the associated molecular mechanisms. Methods BALB/c nude mice were injected with […]