Highlights Small-litter promotes greater body weight gain, adiposity, and metabolic abnormalities in adulthood. Small-litter -adult obese rats showed augmented hypothalamic expression of GLP1-R and Lep-R. Swimming training throughout life avoids obesity and metabolic disorders in small-litter-adult rats. Regular exercise can normalize GLP1-R and Lep-R hypothalamic expressions in small-litter-adult rats. ABSTRACT Objective: Glucagon-like peptide-1 (GLP1) and leptin (Lep) are afferent signals that regulate energy metabolism. Lactational hypernutrition results in hyperphagia and adiposity in adult life, and these events can be prevented […]
