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10/Sep/2024
DOI: 10.31744/einstein_journal/2024AO0412
Highlights Klotho controls cellular pathways and is a key factor in senescence and longevity. FGF-23 regulates phosphorus and vitamin D metabolism in a Klotho-dependent manner. Bone formation in Klotho-deficient mice decreased similar to that in aged humans. Renal function and lumbar spine bone mineral density were related to Klotho and FGF-23, respectively. ABSTRACT Objective: To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals. Methods: A total of 55 individuals […]
Keywords: Aged; Biomarkers; Bone density; FGF-23 protein; Human; Klotho protein; Longevity