Highlights ■ EDAcw objectively quantifies sweating in patients with hyperhidrosis. ■ Sympathectomy significantly reduced EDAcw and  improved the quality of life. ■ The hands showed a 97% reduction in electrodermal activity postoperatively. ■ EDAcw is a reliable non-invasive tool for clinical evaluation and follow-up. ABSTRACT Objective: To analyze continuous exosomatic electrodermal activity (EDA) without external stimuli (EDAcw) in patients with primary hyperhidrosis before and after sympathectomy. Methods: This prospective study included 28 participants, categorized into two groups. The first group […]