2 results
23/May/2023
DOI: 10.31744/einstein_journal/2023AO0156
Highlights Viral suppression improved after introducing a dolutegravir-based regimen. HIV viral loads <50 copies/mL were lower than expected (<90%). Higher viral suppression was found when antiretroviral therapy adherence/alterations were controlled (per-protocol analysis). Some baseline characteristics can influence the effectiveness of first-line antiretroviral therapy. ABSTRACT Objective To compare viral suppression in treatment-naïve adults starting antiretroviral therapy with dolutegravir (50mg)- and efavirenz (600mg)-based regimens. Methods We analyzed secondary data from Brazilian health information systems of people living with human immunodeficiency virus who […]
Keywords: Anti-HIV agents; Antiretroviral therapy, highly active; Dolutegravir; Drug therapy, combination; Efavirenz; Effectiveness; HIV-1; Sustained virologic response; Viral load
29/Mar/2022
29/Mar/2022
DOI: 10.31744/einstein_journal/2022AO6453
ABSTRACT Objective To evaluate the therapeutic response (functionality) and its associated factors in patients on biological drugs on the Public Health System for treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Methods An open prospective cohort was carried out from 2011 to 2019, in Belo Horizonte (MG). Functionality was assessed using the Health Assessment Questionnaire Disability-Index at baseline, and after 6 and 12 months of follow-up. Factors associated with poor functionality were identified through logistic regression. Results The median […]
Keywords: Arthritis, psoriatic; Arthritis, rheumatoid; Biological products; Effectiveness; Rheumatic diseases; Spondylitis, ankylosing; Unified Health System