Highlights ■ The institutional nutritional program in tertiary care was effective in promoting moderate weight loss. ■ Obese patients with high cardiovascular risk undergoing multi-drug therapy showed significant improvement in anthropometric, biochemical, and heart rate variability components. ■ Heart rate variability analysis revealed enhanced autonomic balance, increased parasympathetic activity, and reduced sympathetic activity after weight loss. ■ Moderate weight loss presents a promising adjunctive strategy for managing cardiovascular risk in obese patients undergoing multi-drug therapy. Abstract Objective: Cardiovascular diseases remain […]