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30/Jul/2025
DOI: 10.31744/einstein_journal/2025AO1154
Highlights ■ Two gene groups with contrasting expression profiles were identified. ■ The ATP1B3 and SLCOB3 gene profiles classified patients with 90% accuracy. ■ The ATP1B3 and SLCOB3 gene signature is a potential predictor of treatment response. ABSTRACT Introduction: Cervical cancer is the fourth most common cancer in women worldwide. Resistance to chemoradiotherapy in cervical cancer has been widely associated with membrane transport-related genes, particularly those encoding efflux transport proteins, such as the ATP-binding cassette family members (including P-glycoprotein), which […]
Keywords: Adenosine triphosphatases; Biomarkers; Carrier proteins; Chemoradiotherapy; Drug resistance, neoplasms; Membrane transport proteins; Solute carrier proteins; Transcriptome; Uterine cervical neoplasms