13/Aug/2025
Atrophic hypothyroidism associated with thyrotropin receptor antibodies
DOI: 10.31744/einstein_journal/2025RC1400
ABSTRACT Hypothyroidism is most frequently caused by Hashimoto’s thyroiditis. While thyrotropin receptor antibodies are well-known in Graves’ disease-induced hyperthyroidism, their role in hypothyroidism is emerging. We report the case of a 37-year-old woman with facial and periorbital edema, weight gain, and hoarseness suggestive of hypothyroidism. Elevated thyroid stimulating hormone (TSH; 131mIU/L) and decreased free thyroxine (0.2ng/dL, 2.6pmol/L) levels confirmed this diagnosis. Laboratory findings showed dyslipidemia, impaired renal function, elevated creatine phosphokinase levels, and anemia. Despite negative results for thyroid peroxidase […]
Keywords: Autoantibodies; Hashimoto disease; Hypothyroidism; Long-acting thyroid stimulator; Pregnancy; Receptors, thyrotropin; Thyroiditis; Thyroiditis, autoimmune; Thyrotropin
06/Nov/2024
Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents
DOI: 10.31744/einstein_journal/2024RC1105
ABSTRACT The development of alloantibodies or autoantibodies is a complication observed in sickle cell disease. Autoimmunization occurs in 7.6-12% of chronically or intermittently transfused patients with sickle cell disease; however, the clinical implications of autoAbs are unclear. Few studies have focused on pediatric sickle cell disease and autoimmune hemolytic anemia. Herein, we present the coexistence of sickle cell disease and autoimmune hemolytic anemia in two adolescent patients, focusing on their pathophysiology, diagnosis, clinical management, and outcomes.
Keywords: Adolescent; Anemia,hemolytic,autoimmune; Anemia,sickle cell; Autoantibodies; Autoimmunity
10/Nov/2023
Anti-ribosomal P (anti-P) antibodies in patients with autoimmune hepatitis
DOI: 10.31744/einstein_journal/2023AO0375
Highlights Autoimmune hepatitis and systemic lupus erythematosus share several clinical features. Anti-P ribosomal antibody is a biomarker for systemic lupus erythematosus. The association between anti-P ribosomal antibody and autoimmune hepatitis has shown conflicting results. Our results showed no association between anti-P ribosomal antibody and autoimmune hepatitis. ABSTRACT Objective: Published studies have shown associations between anti-ribosomal P (anti-P) antibody and systemic lupus erythematosus with hepatic manifestations. This has been reported also in autoimmune hepatitis. However, the consistency of the latter association […]
Keywords: Autoantibodies; Enzyme-linked immunosorbent assay; Hepatitis, autoimmune; Luminescence; Lupus erythematosus, systemic; Ribosomal proteins
22/Jan/2020
Comparison between enzyme-linked immunosorbent assay and indirect immunofluorescence for detection of antineutrophil cytoplasmic antibodies
einstein (São Paulo). 22/Jan/2020;18:eAO5132.
View Article22/Jan/2020
Comparison between enzyme-linked immunosorbent assay and indirect immunofluorescence for detection of antineutrophil cytoplasmic antibodies
DOI: 10.31744/einstein_journal/2020AO5132
ABSTRACT Objective To evaluate the performance of enzyme-linked immunosorbent assay and indirect immunofluorescence methods for the detection of antineutrophil cytoplasmic antibodies in a routine clinical laboratory setting. Methods A total of 227 samples were tested by indirect immunofluorescence and enzyme-linked immunosorbent assay with antigen specificity for antiproteinase 3 and antimyeloperoxidase. The proportions of positive samples were compared by McNemar hypotheses and agreement was described by Cohen’s Kappa coefficient. Results The agreement of the tests was 96.5%, and the Kappa coefficient […]
Keywords: Antibodies, antineutrophil cytoplasmic; Autoantibodies; Autoimmune diseases; Enzyme-linked immunosorbent assay; Fluorescent antibody technique, indirect
01/Apr/2011
Incidence of alloimunization in sickle cell disease: experience of a center in São Paulo
DOI: 10.1590/S1679-45082011AO2003
ABSTRACT Objective: To identify the incidence of alloimmunization in sickle cell disease patients, as well as autoantibodies and the phenotypic profile of these patients for the following erythrocyte antigen groups: Rh, Kell, Kidd, Duffy and MNS. Methods: fifty-seven patients were evaluated during follow-up at the Anemia Outpatient Clinic of Irmandade da Santa Casa de São Paulo, where a search for irregular antibodies and phenotyping was carried out. Results: Patients’ median alloimmunization age in sickle cell disease was 25 years, and […]
Keywords: Anemia, sickle cell/immunology; Autoantibodies; Blood group antigens; Blood transfusion