22/set/2025
Expression profiles of miR-23a andmiR-146a in the peripheral blood of women with premature ovarian insufficiency
DOI: 10.31744/einstein_journal/2025AO1421
INTRODUCTION Premature ovarian insufficiency (POI) is a clinical syndrome characterized by oligo/amenorrhea observed in women before the age of 40 years, lasting at least 4 months, with elevated follicle-stimulating hormone (FSH) levels.() Its diagnosis is confirmed by two serum measurements conducted at least 1 month apart that show high FSH levels (>25IU/L) and low estradiol levels.() The condition is caused by varying factors, including genetic, immunological, or metabolic factors; iatrogenic intervention; and environmental toxins. The reason is idiopathic in 90% […]
Palavras-chave: Autoimmunity; Biomarcadores; Inflamação; MicroRNAs; Peripheral blood; Primary ovarian insufficiency
12/set/2025
Inflammatory response to elective percutaneous coronary intervention is related to myocardial injury
einstein (São Paulo). 12/set/2025;23:eAO1582.
Ver Artigo12/set/2025
Inflammatory response to elective percutaneous coronary intervention is related to myocardial injury
DOI: 10.31744/einstein_journal/2025AO1582
Highlights ■ Previous studies have correlated inflammation with complications after percutaneous coronary intervention. ■ In patients with stable coronary disease, percutaneous coronary intervention leads to elevated inflammatory biomarker levels. ■ The inflammatory response is significantly correlated with myocardial injury. ABSTRACT Introduction: In acute coronary syndrome, the release of inflammatory and myocardial injury biomarkers after percutaneous coronary intervention is associated with poor prognosis. However, little is known about the association between these biomarkers in patients with stable disease. Objective: We aimed […]
Palavras-chave: Síndrome coronariana aguda; Biomarcadores; Inflamação; Myocardial injury; Neutrophis; Percutaneous coronary intervention; Prognóstico; Systemic inflammatory response
30/jul/2025
High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis
einstein (São Paulo). 30/jul/2025;23:eAO1345.
Ver Artigo30/jul/2025
High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis
DOI: 10.31744/einstein_journal/2025AO1345
Highlights ■ MMP-1, MMP-2, and MMP-3 are upregulated in endometriotic lesions. ■ The study findings suggest a senescence-associted secretory phenotype in endometriosis. ■ The study findings support targeting senescence pathways in endometriosis. ABSTRACT Objective: To investigate the roles of cellular senescence and dysfunctional extracellular matrix metalloproteinases (MMPs) in perpetuating chronic inflammation and facilitating the establishment of endometriotic lesions. By analyzing the MMP activity in the endometrial tissue and peritoneal fluid, we aimed to obtain novel insights into the molecular mechanisms […]
Palavras-chave: Senescência celular; Endometriose; Matriz extracelular; Inflamação; Metalloproteinases; Senescence-associated secretory phenotype
26/nov/2024
Use of convalescent plasma in COVID-19 treatment: is clinical severity more important than the intervention?
einstein (São Paulo). 26/nov/2024;22:eAO0563.
Ver Artigo26/nov/2024
Use of convalescent plasma in COVID-19 treatment: is clinical severity more important than the intervention?
DOI: 10.31744/einstein_journal/2024AO0563
Highlights ■ Convalescent plasma did not affect the outcomes. ■ Convalescent plasma improved some laboratory parameters but had no impact on clinical outcomes. ■ Dialysis and the World Health Organization severity score on day 0 influenced the outcomes. ABSTRACT Objective: This study compared the outcomes of two cohorts of patients with coronavirus disease 2019 (COVID-19) who received COVID-19 convalescent plasma transfusions between 2020 and 2021. Methods: This retrospective study was conducted at a tertiary hospital in São Paulo, Brazil. We […]
Palavras-chave: COVID-19 serotherapy; Dialysis; Hospitalização; Imunização passiva; Inflamação; Plasma
21/nov/2024
Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review
einstein (São Paulo). 21/nov/2024;22:eRW0936.
Ver Artigo21/nov/2024
Effects of host modulation through omega-3 dietary supplementation on inflammatory outcomes in periodontitis: a scoping review
DOI: 10.31744/einstein_journal/2024RW0936
ABSTRACT Objective: Inflammation causes the progressive destruction of the supporting tissues around teeth in patients with periodontitis. Therefore, this study aimed to investigate the immunological effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as adjunctive therapy in patients with periodontal disease and identify potential biomarkers for the disease. Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to investigate the impact of omega-3 therapy with or without acetylsalicylic acid on the immunological parameters of […]
Palavras-chave: Citocinas; Fatty acids; Inflamação; Omega-3; Periodontite
22/jul/2024
Inflammation and all-cause mortality in patients undergoing peritoneal dialysis
DOI: 10.31744/einstein_journal/2024AO0627
Highlights Higher plasma levels of CCL2 and lower plasma levels of TNF-α are associated with a greater risk of transfer to hemodialysis or mortality. Lower levels of IL-17 in the dialysate are associated with a greater risk of transfer to hemodialysis or mortality. These findings suggest that inflammatory biomarkers can be valuable tools for predicting all-cause mortality and transfer to hemodialysis in patients undergoing peritoneal dialysis. ABSTRACT Objective: This study aimed to evaluate inflammatory biomarkers in patients undergoing peritoneal dialysis […]
Palavras-chave: Citocinas; Inflamação; Membranes; Mortality; Diálise peritoneal; Peritoneum
19/out/2023
Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model
einstein (São Paulo). 19/out/2023;21:eAO0465.
Ver Artigo19/out/2023
Articular mobilization promotes improvement in functional and inflammatory parameters in a gouty arthritis model
DOI: 10.31744/einstein_journal/2023AO0465
Highlights The predominance of neutrophils was observed in an acute model of gout in mice, where neutrophils were mobilized and gradually replaced by monocytes/macrophages, with attenuation of the influence of leukocyte infiltration in the synovial fluid. Mobilization promotes analgesia and modulates the inflammatory process due to reduced edema and subtle attenuation of cell migration. At the inflammatory peak in a gouty arthritis model, manual therapy and passive joint mobilization decrease nociception and edema in functional and inflammatory parameters. ABSTRACT Objective: […]
Palavras-chave: Arthritis, gouty; Edema; Inflamação; Leukocytes; Models, theoretical; Ratos Wistar; Synovial fluid
01/jun/2022
Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring
einstein (São Paulo). 01/jun/2022;20:eAO6778.
Ver Artigo01/jun/2022
Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring
DOI: 10.31744/einstein_journal/2022AO6778
ABSTRACT Objective: To investigate the effect of pre and postnatal exposure to a glyphosate-based herbicide on glucose metabolism and liver histology in adult F1 mice offspring. Methods: Female mice (C57Bl/6) received 0.5% of glyphosate (Roundup Original DI®) in drinking water or purified water (Glyphosate Group and Control Group respectively) during pregnancy and lactation. Offspring (F1) were submitted to glucose and insulin tolerance tests and euthanized on postnatal day 150. Body and plasma parameters, and liver histology were analyzed. Results: Exposure […]
Palavras-chave: Endocrine disruptors; Glucose metabolism disorders; Glifosato; Herbicides; Inbred C57BL; Inflamação; Camundongos
14/nov/2019
Evolução da relação neutrófilo-linfócito após gastrectomia curativa por câncer gástrico: análise de subgrupos
DOI: 10.31744/einstein_journal/2020AO4860
RESUMO Objetivo: Avaliar o impacto da alteração da relação neutrófilo-linfócito após ressecção curativa por câncer gástrico. Métodos: Realizou-se análise retrospectiva de pacientes com câncer gástrico submetidos à gastrectomia curativa entre 2009 e 2017. Foi estabelecido valor de corte para a relação neutrófilo-linfócito nos períodos pré e pós-operatório de acordo com a mediana, e quatro subgrupos foram formados (baixo-baixo/baixo-alto/alto-baixo/alto-alto). Dados clínicos e patológicos e de sobrevida foram analisados e relacionados com estes subgrupos. Resultados: Foram incluídos no estudo 325 pacientes. Os […]
Palavras-chave: Biomarcadores; Gastrectomia; Inflamação; Neoplasias gástricas; Prognóstico
Exercícios físicos de resistência, hipertrofia e força muscular reduzem igualmente adiposidade, inflamação e resistência à insulina em camundongos obesos por dieta hiperlipídica

17/set/2019
Exercícios físicos de resistência, hipertrofia e força muscular reduzem igualmente adiposidade, inflamação e resistência à insulina em camundongos obesos por dieta hiperlipídica
einstein (São Paulo). 17/set/2019;18:eAO4784.
Ver Artigo17/set/2019
Exercícios físicos de resistência, hipertrofia e força muscular reduzem igualmente adiposidade, inflamação e resistência à insulina em camundongos obesos por dieta hiperlipídica
DOI: 10.31744/einstein_journal/2020AO4784
RESUMO Objetivo Avaliar os efeitos de três tipos de treinamentos de resistência na adiposidade, na inflamação e na ação da insulina em camundongos Swiss obesos por dieta hiperlipídica. Métodos Camundongos Swiss machos magros e obesos foram selecionados e posteriormente separados em oito grupos com oito animais em cada: dieta padrão + não treinado; dieta padrão + treinamento de resistência muscular; dieta padrão + treinamento de hipertrofia; dieta padrão + treinamento de força; dieta hiperlipídica + não treinado; dieta hiperlipídica + […]
Palavras-chave: Camundongos; Exercício; Inflamação; Insulina/metabolismo; Obesidade; Perda de peso; Resistência à insulina; Treinamento de resistência