2 results
26/Feb/2025
DOI: 10.31744/einstein_journal/2025RC1236
ABSTRACT A 49-year-old woman presented with a 16-year history of burning pain, warmth, redness, and edema in both toes, feet, legs and calves. Despite extensive medical testing, including genetic analysis, no specific cause was identified. Initial treatments failed to improve symptoms, leading to impaired quality of life and mental health. Eventually, a six-month course of intravenous immunoglobulin therapy provided complete relief, allowing the patient to resume normal activities. Erythromelalgia is a rare neurovascular condition characterized by pain, warmth, and erythema […]
Keywords: Autoimmune diseases; Erythromelalgia; Immunoglobulins, intravenous; NAV17 Voltage-gated sodium channel; Small fiber neuropathy
05/Jul/2022
05/Jul/2022
DOI: 10.31744/einstein_journal/2022MD8044
ABSTRACT Skin biopsy with investigation of small-diameter nerve fibers in human epidermis and dermis has been proven to be a useful method for confirming small-fiber neuropathy. In medical practice, small-fiber neuropathy is increasingly recognized as a leading cause of neuropathic pain. It is a prevalent complaint in medical offices, brought by patients often as a “painful burning sensation”. The prevalence of neuropathic pain is high in small-fiber neuropathies of different etiologies, especially in the elderly; 7% of population in this […]
Keywords: Biopsy; Diabetes mellitus; Diabetic neuropathies; Drug therapy; Fabry disease; HIV; Nerve fibers; Neuralgia, postherpetic; Rheumatic diseases; Skin; Small fiber neuropathy