ABSTRACT Epiphyseal displacement of the distal humerus is rare and difficult to diagnose. In addition, the literature on the prognosis and treatment is limited. Here, we present a case of distal humeral physeal separation with significant displacement in a neonate. A favorable outcome was obtained following closed reduction and percutaneous fixation with Kirschner wires assisted by arthrography. This report adds valuable information on this subject to the existing literature.