13/Aug/2025
Atrophic hypothyroidism associated with thyrotropin receptor antibodies
DOI: 10.31744/einstein_journal/2025RC1400
ABSTRACT Hypothyroidism is most frequently caused by Hashimoto’s thyroiditis. While thyrotropin receptor antibodies are well-known in Graves’ disease-induced hyperthyroidism, their role in hypothyroidism is emerging. We report the case of a 37-year-old woman with facial and periorbital edema, weight gain, and hoarseness suggestive of hypothyroidism. Elevated thyroid stimulating hormone (TSH; 131mIU/L) and decreased free thyroxine (0.2ng/dL, 2.6pmol/L) levels confirmed this diagnosis. Laboratory findings showed dyslipidemia, impaired renal function, elevated creatine phosphokinase levels, and anemia. Despite negative results for thyroid peroxidase […]
Keywords: Autoantibodies; Hashimoto disease; Hypothyroidism; Long-acting thyroid stimulator; Pregnancy; Receptors, thyrotropin; Thyroiditis; Thyroiditis, autoimmune; Thyrotropin