19/ago/2025
Overall and disease-free survival in patients with HPV-positive and HPV-negative oropharyngeal cancer
DOI: 10.31744/einstein_journal/2025AO1525
Highlights ■ HPV+ is associated with improved overall survival in oropharyngeal cancer ■ HPV+ tumors tend to recur earlier than HPV- tumors. ■ Metastasis is a key prognostic factor for mortality and recurrence regardless of HPV status. ■ Smoking and alcohol consumption reduce the favorable prognosis of HPV+. ABSTRACT Objective: To analyze the overall and disease-free survival of patients with oropharyngeal squamous cell carcinoma. Methods: Sociodemographic and clinical data, HPV status, and alcohol/tobacco consumption were assessed among patients treated at […]
Palavras-chave: Disease-free survival; Human papillomavirus viruses; Oropharyngeal neoplasms; Prognóstico; Recidiva; Squamous cell carcinoma of head and neck; Taxa de sobrevida
08/ago/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/ago/2025;23:eAO1601.
Ver Artigo08/ago/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Palavras-chave: Biomarcadores; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Linfonodos; Prognóstico; Neoplasias da próstata
25/set/2024
Acute kidney injury in coronavirus disease: a comparative study of the two waves in Brazil
DOI: 10.31744/einstein_journal/2024AO0687
ABSTRACT Highlights Renal involvement was frequent in patients with COVID-19 and related to worse outcomes. Diuretic use, mechanical ventilation, proteinuria, hematuria, age, and creatine phosphokinase and D-dimer levels were risk factors for acute kidney injury. Acute kidney injury, mechanical ventilation, elevated SOFA Score, and elevated ATN-ISS were associated with mortality. The second wave was associated with greater severity; however, the mortality rates were similar between the two periods. This may reflect the effectiveness of vaccines and the constant learning that […]
Palavras-chave: Acute kidney injury; Brasil; Infecções por coronavírus; COVID-19; Incidence; Mortality; Prognóstico; Receptor cross-talk
07/mar/2023
Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?
einstein (São Paulo). 07/mar/2023;31:eAO0172.
Ver Artigo07/mar/2023
Cancer patients with COVID-19: does prior nutritional risk associated with cancer indicate a poor prognosis for COVID-19?
DOI: 10.31744/einstein_journal/2023AO0172
Highlights Patients at nutritional risk had a lower survival than those not at nutritional risk. Nutritional risk had good discriminatory accuracy to predict death. Nutritional screening should be included as an essential part of care for these patients. ABSTRACT Objective To verify whether the presence of related nutritional risk indicators prior to COVID-19 diagnosis is associated with poor survival in patients with cancer. Methods We retrospectively analyzed the data of hospitalized cancer patients who tested positive for COVID-19 between […]
Palavras-chave: Coronavirus; Infecções por coronavírus; COVID-19; Desnutrição; Neoplasias; Estado nutricional; Prognóstico
19/dez/2022
Molecular profile of patients with myelofibrosis: a 10-year experience
DOI: 10.31744/einstein_journal/2023AO0100
Highlights Karyotype was normal in 60% of patients and altered in 40%. The variants most often detected in the myeloid panel were: JAK2 (54%), ASXL1 (50%), TET2 (31%), and CALR (22%). The median follow-up of transplant patients was 2.4 years and the two-year overall survival was 80%. ABSTRACT Objective To analyze the karyotype test and myeloid panel with next-generation sequencing findings in patients with myelofibrosis, and to compare transplant characteristics in patients referred for bone marrow transplantation. Methods Retrospective, […]
Palavras-chave: Bone marrow transplantation; Análise citogenética; Mutação; Primary myelofibrosis; Prognóstico
20/maio/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
einstein (São Paulo). 20/maio/2022;20:eAO6953.
Ver Artigo20/maio/2022
Prognostic factors of worse outcome for hospitalized COVID-19 patients, with emphasis on chest computed tomography data: a retrospective study
DOI: 10.31744/einstein_journal/2022AO6953
ABSTRACT Objective: To evaluate anthropometric and clinical data, muscle mass, subcutaneous fat, spine bone mineral density, extent of acute pulmonary disease related to COVID-19, quantification of pulmonary emphysema, coronary calcium, and hepatic steatosis using chest computed tomography of hospitalized patients with confirmed diagnosis of COVID-19 pneumonia and verify its association with disease severity. Methods: A total of 123 adults hospitalized due to COVID-19 pneumonia were enrolled in the present study, which evaluated the anthropometric, clinical and chest computed tomography data […]
Palavras-chave: Infecções por coronavírus; COVID-19; Tomografia computadorizada multidetectores; Obesidade; Pneumonia; Prognóstico; Funções verossimilhança; X-ray computed
15/dez/2021
O atraso no diagnóstico do câncer de mama durante a pandemia da COVID-19 em São Paulo, Brasil
DOI: 10.31744/einstein_journal/2021AO6721
RESUMO Objetivo Avaliar o impacto da pandemia da COVID-19 no diagnóstico de câncer de mama em um centro de imagem de mama. Métodos Estudo de coorte retrospectivo que incluiu mulheres submetidas a exames e procedimentos de mama em um hospital privado em São Paulo, SP, Brasil, no período de medidas mais rigorosas de isolamento social em 2020 (dividido em primeiro período, de 24 de março a 21 de junho de 2020, e em segundo período, de 22 de junho a […]
Palavras-chave: Brasil; COVID-19; Detecção precoce de câncer; Espectroscopia de ressonância magnética; Infecções por coronavírus; Mamografia; Neoplasias da mama; Prognóstico; Rastreamento de câncer de mama; Ultrassonografia mamária
14/nov/2019
Evolução da relação neutrófilo-linfócito após gastrectomia curativa por câncer gástrico: análise de subgrupos
DOI: 10.31744/einstein_journal/2020AO4860
RESUMO Objetivo: Avaliar o impacto da alteração da relação neutrófilo-linfócito após ressecção curativa por câncer gástrico. Métodos: Realizou-se análise retrospectiva de pacientes com câncer gástrico submetidos à gastrectomia curativa entre 2009 e 2017. Foi estabelecido valor de corte para a relação neutrófilo-linfócito nos períodos pré e pós-operatório de acordo com a mediana, e quatro subgrupos foram formados (baixo-baixo/baixo-alto/alto-baixo/alto-alto). Dados clínicos e patológicos e de sobrevida foram analisados e relacionados com estes subgrupos. Resultados: Foram incluídos no estudo 325 pacientes. Os […]
Palavras-chave: Biomarcadores; Gastrectomia; Inflamação; Neoplasias gástricas; Prognóstico
17/jan/2019
Receptor hormonal negativo como fator preditivo para resposta patológica completa ao tratamento neoadjuvante de câncer de mama
einstein (São Paulo). 17/jan/2019;17(1):eAO3434.
Ver Artigo17/jan/2019
Receptor hormonal negativo como fator preditivo para resposta patológica completa ao tratamento neoadjuvante de câncer de mama
DOI: 10.31744/einstein_journal/2019AO3434
RESUMO Objetivo Definir um fator preditivo para resposta patológica completa, comparar os resultados oncológicos associados com o grau de resposta patológica, após quimioterapia neoadjuvante, e analisar a resposta patológica completa como fator prognóstico para sobrevivência global e livre de progressão de doença. Métodos Estudo retrospectivo de pacientes admitidas no Hospital Estadual Mário Covas e Hospital Anchieta, no período de 2008 a 2012, com câncer de mama localmente avançado. Foram utilizados status dos receptores hormonais, proteína HER2, grau histológico e nuclear, […]
Palavras-chave: Neoplasias da mama/patologia; Prognóstico; Sobrevivência (Saúde Pública); Terapia neoadjuvante; Valor preditivo dos testes
04/jul/2018
Câncer de boca e orofaringe: epidemiologia e análise da sobrevida
DOI: 10.1590/S1679-45082018AO4248
RESUMO Objetivo Avaliar o perfil epidemiológico e a taxa de sobrevida do câncer de boca e orofaringe de pacientes atendidos em um hospital universitário. Métodos Foi realizado um estudo transversal por meio dos laudos anatomopatológicos dos pacientes com câncer de boca e orofaringe atendidos em um hospital universitário, na Região Sul, entre janeiro de 2004 a dezembro de 2014. A partir destes laudos, foram coletadas informações sobre o paciente e o tumor. A taxa de mortalidade foi obtida do registro […]
Palavras-chave: Neoplasias bucais/epidemiologia; Neoplasias orofaríngeas/epidemiologia; Prognóstico; Taxa de sobrevida