08/ago/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
einstein (São Paulo). 08/ago/2025;23:eAO1601.
Ver Artigo08/ago/2025
Interconnected study of molecular pathways: miR-137 as a central element at the intersection of lipid metabolism and prostate carcinogenesis
DOI: 10.31744/einstein_journal/2025AO1601
Highlights ■ The reduction of miR-137 in tumor tissues is associated with a worse prognosis. ■ miR-137 has eight oncogenically relevant target genes acting in the PPARα lipid pathway. ■ NCOA1, NCOA3, MED27, and ESRRA are associated with advanced prostate cancer. ■ miR-137 exhibits significant clinical potential by repressing the activation of pathways that influence prostate tumorigenesis in hyperstimulated metabolic environments. ABSTRACT Objective: To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. Methods: […]
Palavras-chave: Biomarcadores; Disease progression; Disease-free survival; Health strategies; Lipid metabolism; Linfonodos; Prognóstico; Neoplasias da próstata
22/abr/2025
Socioeconomic inequities in prostate cancer care: private versus public treatment settings pose a significant impact on overall survival
einstein (São Paulo). 22/abr/2025;23:eAO0851.
Ver Artigo22/abr/2025
Socioeconomic inequities in prostate cancer care: private versus public treatment settings pose a significant impact on overall survival
DOI: 10.31744/einstein_journal/2025AO0851
Highlights ■ Men with metastatic prostate cancer in the public system have access to fewer treatment lines. ■ Survival in the public system was 3 years shorter than that in the private setting (78 versus 115 months). ABSTRACT Objective: To evaluate the impact of assistance from public and private health systems on the overall survival of patients with metastatic prostate cancer. Methods: A total of 213 patients with metastatic prostate cancer treated at the A.C. Camargo Cancer Center, either in […]
Palavras-chave: Brasil; Serviços de Saúde; Sistemas de saúde; Metástase neoplásica; Private sector; Neoplasias da próstata; Public sector; Race factors; Social determinants of health; Análise de sobrevida
31/out/2024
Irreversible electroporation for prostate cancer: another promising focal therapy
DOI: 10.31744/einstein_journal/2024RC0779
ABSTRACT Radical treatment for prostate cancer is associated with significant morbidity. Percutaneous image-guided irreversible electroporation is a non-thermal ablative technique that has emerged as a valuable option. This study describes the case of a patient with prostate cancer who was successfully treated using irreversible electroporation. We report the case of a 72-year-old male patient who presented with elevated PSA (4.0ng/mL) during routine testing. Multiparametric magnetic resonance imaging of the prostate revealed a 0.8 cm lesion in the posterolateral aspect of […]
Palavras-chave: Ablation techniques; interventional; Irreversible electroporation therapy; Multiparametric magnetic resonance imaging; Neoplasias da próstata; Radiology
11/out/2023
Epidemiological profile of COVID-19 in patients with prostate cancer undergoing androgen deprivation therapy at a Brazilian Cancer Center
einstein (São Paulo). 11/out/2023;21:eAO0273.
Ver Artigo11/out/2023
Epidemiological profile of COVID-19 in patients with prostate cancer undergoing androgen deprivation therapy at a Brazilian Cancer Center
DOI: 10.31744/einstein_journal/2023AO0273
Highlights We were unable to prove an association between the use of androgen deprivation therapy and a reduction in factors associated with worse clinical outcomes. Most of the data presented show a tendency to favor the outcomes of patients who do not undergo androgen deprivation therapy, which can be explained by the fact that, in general, their clinical conditions are better and their performance status scores are lower than those of patients who undergo androgen deprivation therapy. ABSTRACT Objective: To […]
Palavras-chave: Androgens; Antineoplásicos; Infecções por coronavírus; COVID-19; hormonal; Neoplasias da próstata; SARS-CoV-2
21/nov/2022
Radical prostatectomies for treatment of prostate cancer: trends in a ten-year period in public health services in the city of São Paulo, Brazil
einstein (São Paulo). 21/nov/2022;20:eAO0049.
Ver Artigo21/nov/2022
Radical prostatectomies for treatment of prostate cancer: trends in a ten-year period in public health services in the city of São Paulo, Brazil
DOI: 10.31744/einstein_journal/2022AO0049
ABSTRACT Objective To analyze the characteristics of public health services related to radical prostatectomy, according to hospital volume of surgeries and stratified as academic and non-academic centers. Methods An ecological study was conducted using a database available in TabNet platform of the Unified Health System Department of Informatics. Number of surgeries, length of hospital stay, length of stay in intensive care unit, in-hospital mortality rate, and cost of hospitalization were evaluated. The hospitals were divided into three subgroups according to […]
Palavras-chave: Prostatectomia; Neoplasias da próstata; Saúde pública
21/nov/2022
Prostate imaging features on magnetic resonance imaging of young patients
DOI: 10.31744/einstein_journal/2022AO0024
ABSTRACT Objective To identify magnetic resonance imaging findings of the prostate in young adults, including symptomatic and asymptomatic patients. The aim of this study is to evaluate the main aspects of prostate imaging in young patients. Methods A total of 102 patients under 40 years of age, who underwent prostate magnetic resonance imaging between January 2016 and January 2019, were included in this study. The patients were divided into two groups: symptomatic for prostatitis (Group 1) and asymptomatic (Group 2). […]
Palavras-chave: Imagem por ressonância magnética; Próstata; Neoplasias da próstata
06/maio/2022
Accuracy of 68Ga-PSMA PET-CT and PET-MRI in lymph node staging for localized prostate cancer
DOI: 10.31744/einstein_journal/2022AO6599
ABSTRACT Objective To evaluate the predictive value of positron emission computed tomography or magnetic resonance (PET-CT and PET-MRI) using gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA) in lymph node involvement in prostate cancer. Methods A retrospective study comprising 91 patients diagnosed with prostate cancer between 2016 to 2020, who underwent 68Ga-PSMA PET-CT or PET-MRI for staging before prostatectomy. The patients were divided into Group 1, with 65 patients with satisfactory pathological lymph node analysis, and Group 2, with 91 patients representing the […]
Palavras-chave: Confiabilidade dos dados; Gallium; Linfonodos; Positron emission tomography computed tomography; Prostate-specific antigen; Prostatectomia; Neoplasias da próstata
22/nov/2021
Conhecimento da população da cidade de São Paulo a respeito do câncer de próstata
DOI: 10.31744/einstein_journal/2021AO6325
RESUMO Objetivo: Avaliar o conhecimento da população da cidade de São Paulo em relação ao câncer de próstata. Métodos: Foram entrevistados randomicamente 392 adultos em espaços públicos da cidade de São Paulo, os quais responderam a um questionário que abordava questões demográficas e de conhecimentos específicos sobre o câncer de próstata. Um escore foi utilizado para avaliar o conhecimento de câncer em geral e do câncer de próstata, considerando um conhecimento satisfatório com escore de 6 pontos. Resultados: A média […]
Palavras-chave: Conhecimento; Inquéritos e questionários; Neoplasias da próstata; Programas de rastreamento
11/jul/2019
Estudo comparativo entre as sequências de difusão monoexponencial e biexponencial na ressonância magnética multiparamétrica da próstata
DOI: 10.31744/einstein_journal/2019AO4615
RESUMO Objetivo: Comparar qualitativa e quantitativamente, em termos de qualidade de imagem, um novo protocolo de sequência de difusão biexponencial com o protocolo de difusão monoexponencial padrão, em ressonância magnética multiparamétrica da próstata. Métodos: Estudo com coleta prospectiva e análise transversal. Entre agosto e novembro de 2017, foram recrutados 70 pacientes que realizaram ressonância magnética multiparamétrica da próstata, por suspeita de neoplasia prostática. As imagens obtidas por ambas as sequências foram avaliadas por dois leitores independentes, quanto a critérios de […]
Palavras-chave: Difusão biexponencial; Difusão monoexponencial; Imagem de difusão por ressonância magnética; Imagem por ressonância magnética; Movimento incoerente intravoxel; Neoplasias da próstata; Ressonância magnética multiparamétrica da próstata
01/jan/2017
PET/RM: um novo método de imagem híbrida. Principais indicações clínicas e experiência preliminar no Brasil
DOI: 10.1590/S1679-45082017MD3793
RESUMO Nos últimos anos, imagens médicas com tecnologias híbridas tornaram-se amplamente aceitas e utilizadas na prática clínica. O PET/RM possui vantagens importantes, incluindo excelentes contrastes e resolução, e menor radiação ionizante, em comparação ao PET/TC. Por isto, é uma modalidade promissora para exames de imagem de pacientes oncológicos, para avaliar o cérebro, cabeça e pescoço, o fígado e a pelve. O objetivo deste artigo foi analisar as situações clínicas que se beneficiariam de exames de PET/RM a partir de uma […]
Palavras-chave: Imagem por ressonância magnética/métodos; Neoplasias da próstata; Neoplasias pélvicas; Neuroimagem; Tomografia computadorizada por raios x/métodos; Tomografia por emissão de pósitrons/métodos