Highlights ■ Accessibility to novel drugs for multiple myeloma render excellent outcomes. ■ Hemoglobin at diagnosis is a significant risk factor. ■ Age also impacts outcomes. ■ Hemoglobin and age-based model fared better than the International Staging System. ABSTRACT Objective: To report the outcomes of patients with multiple myeloma who had access to novel drugs in Brazil, and to establish a local benchmark. Methods: This prospective observational study was conducted at Hospital Israelita Albert Einstein in São Paulo, Brazil. We […]

ABSTRACT This case report describes a male patient diagnosed with multiple myeloma who experienced significant bleeding from both the maxillary and mandibular dental sockets following dental extraction, lasting several days. Laboratory tests revealed prolonged prothrombin time and thrombin time, accompanied by reduced factor VII levels. Initial management with intravenous vitamin K and fresh frozen plasma failed to achieve hemostasis. Despite the risk of thrombosis, low-dose tranexamic acid was initiated, resulting in effective hemorrhage control and improved healing of the alveolar […]

Highlights Lymphoproliferative disorders were associated with lower vaccine response rates than other disorders. Previous exposure to COVID-19 before vaccination was associated with higher antibody values. The duration of anti-B-lymphocyte therapy related to vaccination had an effect on response rates. The incidence of adverse effects of patients with onco-hematological diseases was similar to that of the healthy population.   ABSTRACT Objective To evaluate the influence of onco-hematological pathologies on seroconversion to COVID-19 vaccines, in addition to the effects of chemotherapy treatment […]

ABSTRACT Objective To describe of the translation from English to Portuguese and adaption process of subitems of the Functional Assessment of Cancer Therapy – Multiple Myeloma. Methods In the first phase, translations from English into Portuguese of two subitems of Functional Assessment of Cancer Therapy – Multiple Myeloma were performed. Subsequently, a consensus and back translation were conducted, and, finally, translation and back translations were reviewed by four independent bilingual experts. In the second phase, the translated subitems were applied, […]

Pacientes diagnosticados com mieloma múltiplo são mais suscetíveis a infecções, que é a principal causa de morbidade e mortalidade associadas a essa doença. Os principais agentes infecciosos envolvidos são as bactérias Gram-positivas, mas, após a quimioterapia, pode haver aumento na incidência de Gram-negativos, que são responsáveis, na maioria dos casos, por infecções do trato urinário. Assim, descrevese um raro caso de um paciente de 73 anos de idade, com mieloma múltiplo diagnosticado com endocardite por pseudomonas.

RESUMO Objetivo: Determinar a sobrevida de pacientes portadores de mieloma múltiplo em 5 anos pós-transplante. Métodos: Estudo retrospectivo em pacientes com diagnóstico de mieloma múltiplo submetidos a transplante autólogo de medula óssea em uma instituição brasileira, no período de 1993 a 2007. Resultados: Foram avaliados 73 pacientes com mediana de idade de 55 anos. A sobrevida encontrada em 5 anos foi de 75% (2,4 a 60 meses). A análise estatística demonstrou significância estatística para o grau de resposta ao tratamento […]