Highlights ■ Evaluation of a corticosteroid-free antiemetic regimen. ■ Primary endpoint: 46% nausea control. ■ Secondary endpoint: 68% emesis control. ■ Comparable to standard four-drug protocols. ABSTRACT Objective: Chemotherapy-induced nausea and vomiting are highly prevalent adverse events that can lead to poor treatment adherence and a decreased quality of life. To the best of our knowledge, the complete omission of dexamethasone from any regimen for preventing nausea and vomiting has not yet been evaluated. This study aimed to evaluate the […]

Highlights This study contributes data on the pharmacogenomics of acetylsalicylic acid. Brazilian data contribute to reducing the lack of diversity in genetic studies examining unrepresented groups. The genetic variants evaluated were not associated with gastrointestinal bleeding. ABSTRACT Objective: The use of acetylsalicylic acid, even in low doses, may be associated with the onset of upper gastrointestinal bleeding as an idiosyncratic response. Considering the role of the genetic background in inter-individual responses to pharmacotherapy, we aimed to investigate the role of […]

ABSTRACT Objective We performed a systematic review of the literature and meta-analysis on the efficacy and safety of hydroxychloroquine to treat COVID-19 patients. Methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and LILACS (January 2019 to March 2021) for patients aged 18 years or older, who had COVID-19 and were treated with hydroxychloroquine versus placebo or standard of care. We also searched the WHO Clinical Trials Registry for ongoing and recently completed studies, and the […]

ABSTRACT Objective So far, at least 18 different severe acute respiratory syndrome coronavirus-2 vaccines have been approved. Until October 2022, 12.8 billion doses had been administered all over the world. Vaccination of high-risk groups and healthcare professionals was initially prioritized. This cross-sectional survey aimed to investigate the occurrence of vaccine side effects, as well as the incidence of COVID-19 among vaccinated healthcare professionals. Methods A survey was structured and shared with healthcare professionals using a digital platform to collect data […]

ABSTRACT Objective To examine associations between potentially inappropriate medication, use and the risk of falls, unplanned hospitalization and death in older patients receiving initial care in a geriatric day hospital due to acute conditions. Methods Cohort study with older adults referred to a geriatric day hospital from 2014 to 2017 due to acute conditions. Patients were submitted to comprehensive geriatric assessment. Use of medications was analyzed according to Beers Criteria 2019. Outcome assessment was based on monthly follow-up telephone calls […]

RESUMO Relato de caso de paciente com imunodeficiência que necessitava de reposição regular de imunoglobulina endovenosa. Ela apresentou um episódio de lesão pulmonar aguda relacionada à transfusão após uso de produto de imunoglobulina diferente daquele que recebia habitualmente. Evoluiu com alterações respiratórias (hipóxia, dispneia e alteração de ausculta pulmonar) minutos após o fim da infusão, necessitando de suporte respiratório não invasivo. A paciente recebeu alta hospitalar após 36 horas, com boa evolução. Obteve recuperação total dos sintomas, sem mais reações […]

RESUMO A febre amarela é uma doença sistêmica que estava controlada graças às efetivas campanhas de combate ao vetor e aos programas de vacinação. Porém, desde 1999, os surtos reiniciaram-se, devido à ineficácia do controle do vetor, levando à necessidade da imunização em larga escala contra o vírus da febre amarela, gerando aumento do risco de ocorrência de reação adversa à vacina. O presente estudo se propôs a relatar o caso de um lactente previamente saudável, que procurou pronto atendimento, […]

RESUMO Objetivo Determinar o perfil dos medicamentos utilizados por automedicação por idosos. Métodos Estudo transversal baseado em entrevistas com idosos atendidos de julho de 2014 a julho de 2015 em um centro de referência na Atenção à Saúde do Idoso de um hospital de ensino. Foram coletadas informações clínicas, demográficas e farmacoterápicas. Resultados Entrevistaram-se 170 idosos, 85,9% eram mulheres e a mediana de idade foi 76 anos. A frequência de automedicação foi 80,5%. Os medicamentos mais utilizados por automedicação foram […]