Highlights ■ Continuous exosomatic electrodermal activity was associated with higher skin conductance levels in patients with hyperhidrosis. ■ Palmoplantar sweating was significantly higher in the hyperhidrosis group than in the control group (p<0.01). ■ Electrodermal activity is an effective and simple method for objectively quantifying sweating in patients with hyperhidrosis. ABSTRACT Objective: To objectively evaluate sweat intensity in patients with primary hyperhidrosis by measuring electrodermal activity using a continuous exosomatic technique without external stimuli. Methods: This prospective and transversal study […]

Highlights ■ Restrictive ligand density can be pathological. ■ Restrictive ligand density can be neutralized. ■ Restrictive ligand density neutralization may the used to heal or prevent disease. ABSTRACT Objective: This study examined the correlation between immunodominance of the major egg antigen Sm-p40234-246, a robust Th1/Th17 anti-egg CD4 T-cell response, and severe liver immunopathology in experimental murine schistosomiasis. It serves as a platform to analyze how varying degrees of immunodominance affect CD4+ T cell modulation and disease outcomes. Methods: We […]

Highlights Psychostimulant use in the studied population revealed the following: ■ Lack of a valid diagnosis, unsupervised use, drug interactions, and adverse effects. ■ Concomitant use of alcohol and drugs and contraindications such as depression/anxiety. ■ Acquisition without prescription and use to improve academic performance. ABSTRACT Objective: To evaluate psychostimulant drug use among academics in the health area of a higher education institution in Minas Gerais, Brazil. Methods: We conducted an online cross-sectional study of 389 university students from various […]

Highlights ■ No baseline differences between the groups icodextrin versus glucose. ■ Icodextrin significantly improved ultrafiltration, extracellular water, and phase angle. ■ Mortality and technique survival did not differ between the groups during follow-up. ABSTRACT Objective: The efficacy of icodextrin versus glucose patients undergoing peritoneal dialysis remains unclear. The study was designed to compare the effects of once-daily long-dwell icodextrin versus glucose on markers of hypervolemia and survival among patients with kidney failure undergoing an unplanned initiation of automated peritoneal […]

Highlights ■ The learning curves for robotic peripheral arterial interventions were short, with optimal procedure and fluoroscopy times and radiation emission achieved after the 3rd procedure. ■ There were no differences in learning curves in relation to previous experience or main focus of work. ABSTRACT Objective: This study tests a suitable model for training robot-assisted peripheral vascular interventions and examines the learning curves of endovascular surgeons with different levels of previous experience and main focus of work, analyzing procedure time, […]

Highlights ■ The electronic health record is the first step in digital transformation. ■ Change Management is essential to support problems identification. ■ Identifying and stratifying negative impacts within the staff’s daily routine is crucial. ■ A new method was created, and the method’s effectiveness was evaluated. ABSTRACT Objective: Identify potential negative impacts arising from implementing an electronic medical record system, classify them according to the level of criticality, and analyze method’s effectiveness after implementation. Methods: The research involved identifying […]

Highlights ■ Probability of infection with a high SARS-CoV-2 viral load depends on mask-wearing habits. ■ The higher probability of infection with high viral load occurs for individuals that don’t use mask regularly [47.3%–79.8%]. ■ For individuals who use masks regularly, the probability is 38.6%–52.1%. ABSTRACT Objective: Previous studies indicated that face masks reduce the probability of infection by SARSCoV- 2 but did not examine the relationship between SARS-CoV-2 viral load and mask usage. This study analyzed this relationship. Methods: […]

Highlights ■ The MCM8 gene is involved in homologous recombination, acting in the ovarian follicles during meiosis II. ■ To the best of our knowledge, this is the first study to report the presence of this variant in a Brazilian woman. ■ The rs138761187 variant had a low incidence; further studies with a larger sample size or focusing on variants at other gene positions may provide insight into the genetic causes of premature ovarian insufficiency. ABSTRACT Introduction: The MCM8 gene […]

Highlights ■ Mechanical ventilation and mortality rates remained stable. ■ The birth rate at <28 weeks’ gestation increased during the evaluation period. ■ The overall rate of dexamethasone administration was low; however, its use was more significant in infants aged <28 weeks. ABSTRACT Objective: To evaluate temporal trends in the use of dexamethasone for the treatment of bronchopulmonary dysplasia in very-low-birth-weight preterm infants. Methods: A cohort study was conducted using an electronic database and medical records of all very low-birth-weight […]

Highlights Herbal medicinal product use was 3.8%, with high formal prescription; however, it is accompanied by a high risk of interactions and redundancy. Unified Health System pharmacies are not the main source of herbal medicinal products, suggesting low service implementation. Women, people with mental disorders, and allopathy simultaneously users should receive attention. Non-white people are less likely to use herbal medicinal product, suggesting inequalities in accessing these treatments. ABSTRACT Objective: To determine the prevalence and factors associated with herbal medicinal […]