Highlights ■ The exercise program reduced the WOMAC score by 50%, VAS score by 53%, and improved isokinetic strength. ■ There were no significant changes in levels of serum COMP, MMPs, or pro-inflammatory cytokines. ■ Biomarker levels did not correlate with clinical improvement outcomes. ■ This exercise program is feasible for knee osteoarthritis management in primary care. ABSTRACT Objective: To evaluate a simplified exercise program for patients with knee osteoarthritis in terms of pain, functionality, muscle strength, and quality of […]