Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals

Klotho controls cellular pathways and is a key factor in senescence and longevity. FGF-23 regulates phosphorus and vitamin D metabolism in a Klotho-dependent manner.
Bone formation in Klotho-deficient mice decreased similar to that in aged humans.
Renal function and lumbar spine bone mineral density were related to Klotho and FGF-23, respectively.

ABSTRACT

Objective:

To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.

Methods:

A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman’s test for association assessments was used for statistical analysis.

Results:

The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.