einstein (São Paulo). 25/jun/2024;22(Suppl 1):STO007.
Underutilization of adjuvant therapy in resected IB-III non-small-cell lung cancer risk model – analysis from the Brazilian registry of lung cancer
DOI: 10.31744/einstein_journal/2024ABS_BTS_STO007
Category: Thoracic Oncology
Introduction:
Despite the proven survival benefits of adjuvant systemic therapy (AT) in resected non-small-cell lung cancer (NSCLC), its underutilization remains a concern.(–)
Objecitve:
This study aims to explore the extent to which socioeconomic disparities influence AT underutilization.
Methods:
Data from the Brazilian Registry of Lung Cancer (2009-2023), was queried for patients with complete surgical resected stage IB-III and stratified based on AT delivery. Demographic, clinical, and pathological variables were evaluated. Logistic regression model was performed. The model’s performance was assessed through detailed analyses of sensitivity, specificity, and the Area under the Receiver Operating Characteristic (AUC-ROC) curve, complemented by the Hosmer–Lemeshow test for evaluating its fit and accuracy.
Results:
Among 427 patients with resected stage IB–III NSCLC eligible for AT, only 38.4% received it. Higher AT delivery rates were observed in stages III/II compared to IB (p<0.001). Factors such as age, insurance, histology, lymphovascular invasion, TNM pathological stage, and pathological node (pN) status were independently associated with AT delivery in univariable analysis (p<0.005). Multivariable logistic regression model revealed that older age, public healthcare system, specific histological types, pneumonectomy, and stage IB were significantly associated with non-receipt of AT (p<0.05), see . The final Multiple Binary Logistic Regression model presents an equation to estimate the likelihood of a patient undergoing solely surgical treatment. This equation is formulated as −5.703 + 0.058×Age + 0.974×PublicHealthSystem + 0.241×CEC + 3.059×LargeCells+Others + 0.868×Pneumonectomy + 0.657×Sublobar + 2.089×StageIB + 0.867×StageIIA + 0.386×StageIIB – 0.251×StageIIIA + 1.207×pNNegative. A calculated probability above 42.5% categorizes a patient for exclusive surgical intervention. The model demonstrates robust discriminative ability, evidenced by an AUC of 0.833 (), high sensitivity at 90.2%, and moderate specificity of 60.0%. The model’s fit was confirmed through the Hosmer-Lemeshow test, with a p≥0.05.
Conclusion:
Underutilization of AT in patients with resected stage IB-III NSCLC is linked to patient, institutional, and pathological factors. Addressing these disparities is crucial, particularly with the advent of new adjuvant therapy options that promise enhanced survival outcomes.
Palavras-chave: Adjuvant therapy; Socioeconomic disparities; Immunotherapy; Non-small-cell lung cancer; Systemic therapy
131