einstein (São Paulo). 06/nov/2024;22:eRC1105.

Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents

Vinícius Reis , Bruna Paccola , Carla Luana , Marlene Pereira

DOI: 10.31744/einstein_journal/2024RC1105

ABSTRACT

The development of alloantibodies or autoantibodies is a complication observed in sickle cell disease. Autoimmunization occurs in 7.6-12% of chronically or intermittently transfused patients with sickle cell disease; however, the clinical implications of autoAbs are unclear. Few studies have focused on pediatric sickle cell disease and autoimmune hemolytic anemia. Herein, we present the coexistence of sickle cell disease and autoimmune hemolytic anemia in two adolescent patients, focusing on their pathophysiology, diagnosis, clinical management, and outcomes.

Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents
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