22/nov/2024
Efficacy of treatment with tumor-infiltrating lymphocytes as adoptive cell therapy: an integrative review
einstein (São Paulo). 22/nov/2024;22:eRW0935.
Ver Artigo22/nov/2024
Efficacy of treatment with tumor-infiltrating lymphocytes as adoptive cell therapy: an integrative review
DOI: 10.31744/einstein_journal/2024RW0935
ABSTRACT Objective: This integrative review article examines the efficacy of adoptive cell therapy using tumor-infiltrating lymphocytes, with a particular focus on the treatment of melanomas and other solid tumors. Methods: The methodology encompasses theme definition, comprehensive database searches, and a critical review of pertinent literature. Of the 1,947 articles initially identified, 15 were meticulously selected based on stringent inclusion and exclusion criteria. Results: The findings suggest that tumor-infiltrating lymphocytes-based therapy is particularly effective in treating metastatic melanomas, as noted by […]
Palavras-chave: Imunoterapia; Immunotherapy, adoptive; Lymphocytes, tumor-infiltrating; Neoplasias
13/nov/2024
Current landscape of clinical use of ex vivo expanded natural killer cells for cancer therapy
DOI: 10.31744/einstein_journal/2024RW0612
ABSTRACT Natural Killer cells are immune leukocytes required for responses against tumor cells and virus-infected cells. In the last decade, natural killer cells have emerged as promising tools in cancer therapy, and clinical studies on patients treated with natural killer cells have revealed increased rates of disease-free survival. In this article, we review results from the major clinical trials that have used natural killer cells for cancer treatment, including their global distribution. We also discuss the major mechanisms of natural […]
Palavras-chave: Criança; Cell- and tissue-based therapy; Feeder cells; Imunoterapia; Natural killer cells; Neoplasias
25/jun/2024
Underutilization of adjuvant therapy in resected IB-III non-small-cell lung cancer risk model – analysis from the Brazilian registry of lung cancer
einstein (São Paulo). 25/jun/2024;22(Suppl 1):STO007.
Ver Artigo25/jun/2024
Underutilization of adjuvant therapy in resected IB-III non-small-cell lung cancer risk model – analysis from the Brazilian registry of lung cancer
DOI: 10.31744/einstein_journal/2024ABS_BTS_STO007
Category: Thoracic Oncology Introduction: Despite the proven survival benefits of adjuvant systemic therapy (AT) in resected non-small-cell lung cancer (NSCLC), its underutilization remains a concern.(–) Objecitve: This study aims to explore the extent to which socioeconomic disparities influence AT underutilization. Methods: Data from the Brazilian Registry of Lung Cancer (2009-2023), was queried for patients with complete surgical resected stage IB-III and stratified based on AT delivery. Demographic, clinical, and pathological variables were evaluated. Logistic regression model was performed. The model’s […]
Palavras-chave: Adjuvant therapy; Imunoterapia; Non-small-cell lung cancer; Socioeconomic disparities; Systemic therapy
25/jun/2024
Comprehensive analysis: efficacy of pembrolizumab as an initial therapy for PD-L1 negative NSCLC
DOI: 10.31744/einstein_journal/2024ABS_BTS_STO010
Category: Thoracic Oncology Introduction: Bronchogenic tumors, predominantly non-small cell type (NSCLC), are a global health concern, with adenocarcinomas, their most common subtype, being most often diagnosed at advanced stages, making it essential to develop effective therapeutic strategies, especially for patients with NSCLC who do not express the PD-L1 (Programmed Death-Ligand 1) protein. Two pivotal studies, Keynote-189() and Keynote-407,() presented their combined results in 2023, after a 5-year follow-up,() concluding that the combination of Pembrolizumab and chemotherapy demonstrated substantial improvements in […]
Palavras-chave: Quimioterapia; Imunoterapia; Neoplasias do pulmão; Non-small-cell-lung; PD-L1 protein
23/fev/2022
Oral ulcers and sarcoid-like reaction in lymph nodes after cemiplimab therapy for locally advanced cutaneous squamous cell carcinoma: a case report
einstein (São Paulo). 23/fev/2022;20:eRC6367.
Ver Artigo23/fev/2022
Oral ulcers and sarcoid-like reaction in lymph nodes after cemiplimab therapy for locally advanced cutaneous squamous cell carcinoma: a case report
DOI: 10.31744/einstein_journal/2022RC6367
ABSTRACT Cemiplimab is a novel programmed death-1 inhibitor recently approved for advanced cutaneous squamous cell carcinoma. Immune-related adverse events derived from cemiplimab are similar to other anti-PD-1 drugs, including gastrointestinal and cutaneous toxicities. Oral immune-related adverse events were not reported with cemiplimab in previous studies; thus this case report warns of the fact that the oral cavity may be a site of immune-related adverse events during programmed death-1 block therapy and that this can lead to significant limitations when not […]
Palavras-chave: Carcinoma de células escamosas; Imunoterapia; Oral ulcer; Neoplasias cutâneas
15/jun/2018
Pneumonite induzida por imunoterapia antineoplásica: relato de casos
DOI: 10.1590/S1679-45082018RC4030
RESUMO A pneumonite secundária à imunoterapia é uma complicação rara, com incidência estimada em cerca de 3%. No entanto, trata-se de uma intercorrência de difícil diagnóstico e com grande morbidade, que tem se tornado um desafio para oncologistas e emergencistas. Foram revisados os casos de cinco pacientes que fizeram uso de anti-PD1 (program cell death receptor antagonist 1) para tratamento antineoplásico e que evoluíram com quadro de pneumonite induzida pelo tratamento. Todos os pacientes apresentaram sintomas respiratórios em vigência de […]
Palavras-chave: AntiPD1/AntiPDL1; Corticosteroide/efeitos adversos; Imunoterapia; Pneumonite/diagnóstico; Relatos de casos