Highlights Intrathecal chemotherapy did not increase overall survival or time to neurologic deterioration. Compared with no treatment, systemic therapy with no intrathecal chemotherapy afforded better overall survival. Intrathecal chemotherapy should not postpone or preclude systemic treatment. ABSTRACT Objective: To evaluate whether intrathecal chemotherapy improves clinical outcomes in patients with meningeal carcinomatosis. Methods: This retrospective cohort study included consecutive patients with breast cancer diagnosed with meningeal carcinomatosis. Clinical and treatment data were collected from the patients’ medical charts. The primary outcome […]

Highlights Computed tomography revealed fibrotic-like lung changes in 10.9% of patients. Higher computed tomography scores were associated with a reduced DLCO (median computed tomography score, 6 versus 3; p=0.016). Fibrotic-like computed tomography changes were more prevalent in patients with DLCO impairment (p<0.001). Reduced DLCO had sensitivity and specificity of 73% and 88%, respectively, for predicting fibrotic-like computed tomography changes. ABSTRACT Objective: The radiological and functional lung sequelae in COVID-19 survivors remain unclear. We compared the chest computed tomography findings of […]

Highlights Samba rehearsals can increase cardiorespiratory function in dancers up to 19% of VO2max. Samba rehearsals can decrease up to 1.9kg of fat mass and increase 1.3kg of lean body mass. In a samba rehearsal session, dancers spend 50% of their time at an intensity above 83% of the maximum. ABSTRACT Objective: To investigate the effect of 12 weeks of rehearsals on cardiorespiratory parameters and body composition in Brazilian samba dancers belonging to a first-league samba school. Methods: Twenty-six women […]

Highlights Diabetes prevalence at 3.2% among women who had preterm births in Brazil. Almost half of the preterm births of pregnant women with diabetes were therapeutic. Predominance of late preterm cesarean sections with large-for-gestational-age babies. ABSTRACT Objective: The objective was to compare the maternal and perinatal characteristics and outcomes between women with and without diabetes in a Brazilian cohort of women with preterm births. Methods: This was an ancillary analysis of the Brazilian Multicenter Study on Preterm Birth, which included […]

Highlights Recent automated hematology analyzers provide additional parameters to the complete blood count. Sixteen laboratories of a medium-sized municipality of Minas Gerais were interviewed. No laboratory released all parameters obtained from the hematological analyzers to the customer. Expanding our knowledge and implementing these parameters in complete blood counts is essential. ABSTRACT Objective: This study aimed to compare the hematological parameters released by hematological analyzers with those released in customer reports. Methods: We conducted a descriptive study in the laboratories of […]

Highlights Foreign body aspiration into the airways is common in adults and children, especially in the extremes of age. Coughing, wheezing, and dyspnea may occur and can be life-threatening. In airway foreign body, clinical suspicion is more important than imaging exams. Bronchoscopy under general anesthesia is safe and effective for removing foreign bodies; it ensures timely relief and prevents further complications. ABSTRACT Objective: To describe the clinical, bronchoscopic, diagnostic, and therapeutic aspects between children and adults. Methods: This retrospective study […]

Highlights Considering Bethesda V and VI as malignant findings, the fine-needle aspiration accuracy was 92%. Fine-needle aspiration showed 94.4% sensitivity and 86.9% specificity compared to histopathology. We found a positive and negative predictive value of 93.9% and 87.9%, respectively. When Bethesda III and IV were included as malignant, accuracy reduced to 80.1%. ABSTRACT Objective: To establish the diagnostic performance of fine-needle aspiration in detecting benign and malignant neoplasm in comparison with post-thyroidectomy histopathological findings among patients who received a thyroidectomy. […]

Highlights There were no differences in the physiological responses to walking between men and women with intermittent claudication. Sex per se is not a factor that demands changes in walking prescription for patients with intermittent claudication. ABSTRACT Objective: Peak oxygen consumption (VO2peak), anaerobic threshold, walking economy, and cardiovascular responses during walking are used to guide and monitor walking training in patients with peripheral artery disease and intermittent claudication. Women with peripheral artery disease and intermittent claudication present greater impairments than […]

Highlights Chronic pain is directly associated with depressive symptoms and frailty. Chronic pain is not directly associated with functional disability. Depression and frailty are both directly associated with functional disabilities. Frailty mediates the association between chronic pain and functional disability. ABSTRACT Objective: To evaluate the direct and indirect effects of chronic pain, depressive symptoms, frailty components, and functional disability through a pathway analysis approach in a sample of community-dwelling older adults. Methods: Data of 419 participants were cross-sectionally evaluated for […]

Highlights Perinatal L-NAME treatment decreased anxiety- and depression-like behaviors in adult mice. Perinatal L-NAME treatment did not promote changes in locomotor activity in adult mice. Perinatal L-NAME treatment did not alter pain perception ABSTRACT Objective: We hypothesized that perinatal manipulations of the nitrergic system would affect adult animal behaviors. Methods: We tested this hypothesis by perinatally administering N(G)-Nitro-L-arginine methyl ester (L-NAME), a non-specific antagonist of nitric oxide synthase for 15 days and assessed anxiety- and depression-like behaviors in adult mice. […]