A revista einstein (São Paulo) - e-ISSN 2317-6385 é dedicada à divulgação de conteúdo científico de alta qualidade para o avanço da nossa compreensão das doenças humanas e com o objetivo de melhorar a prevenção, o cuidado, o diagnóstico e o tratamento de pacientes em todo o mundo.
Dear Editor,
On March 11, 2020, the World Health Organization (WHO) characterized the coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a pandemic.(1) The novel coronavirus disease has originated as a cluster of unexplained cases of pneumonia in Wuhan, China, and it has scaled to new heights of mortality by affecting people both physically and mentally.[…]
Mental health in the post COVID-19 era: future perspectives
CostaACS, MenonV, PhadkeR, DapkeK, MirandaAV, AhmadS, EssarMY, et al. Mental health in the post COVID-19 era: future perspectives. Einstein (Sao Paulo). 2022;20:eCE6760. https://doi.org/10.31744/einstein_journal/2022CE6760
Costa,Ana Carla dos Santos; Menon,Vaishnavi; Phadke,Rachana; Dapke,Kartik; Miranda,Adriana Viola; Ahmad,Shoaib; Essar,Mohammad Yasir; Hashim,Talib. Mental health in the post COVID-19 era: future perspectives. Einstein (Sao Paulo)., v. 20, eCE6760, abr. 2022. https://doi.org/10.31744/einstein_journal/2022CE6760
Costa,A.C.S., Menon,V., Phadke,R., Dapke,K., Miranda,A.V., Ahmad,S., Essar,M.Y., & Hashim,T. (2022). Mental health in the post COVID-19 era: future perspectives. Einstein (Sao Paulo).,20, eCE6760. https://doi.org/10.31744/einstein_journal/2022CE6760
Costa,Ana Carla dos Santos and Menon,Vaishnavi and Phadke,Rachana and Dapke,Kartik and Miranda,Adriana Viola and Ahmad,Shoaib and Essar,Mohammad Yasir and Hashim,Talib. Mental health in the post COVID-19 era: future perspectives. Einstein (Sao Paulo). [online]. 2022, vol. 20, [cited 2026-06-29], eCE6760. Available from: <https://journal.einstein.br/pt-br/article/mental-health-in-the-post-covid-19-era-future-perspectives/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2022CE6760
Figure 5
DNA triple helix (triplex) structures. A) Three-dimensional view of an intramolecular DNA triplex solved by solution-state nuclear magnetic resonance (PDB ID: 1BCB). The structure was deposited by Asensio et al. (1998) and classified as DNA without mutations.(20) This triple helical arrangement illustrates the association of a third strand with the canonical duplex, stabilized by Hoogsteen interactions. B) Simplified schematic (adapted from Brazda et al., 2020; and Holder et al., 2015) illustrating the principle of triplex formation.(22,23) The canonical duplex is stabilized by Watson–Crick base pairs, while the third strand binds in the major groove via Hoogsteen hydrogen bonds. The chemical structure shown in green corresponds to adenine from the third strand, forming a representative T·A·T triad with a Watson–Crick A·T base pair. Such alternative base-pairing interactions enable an additional strand to associate with duplex DNA through Hoogsteen hydrogen bonding, generating a triple-helical structure capable of modulating essential processes such as replication and transcription