A revista einstein (São Paulo) - e-ISSN 2317-6385 é dedicada à divulgação de conteúdo científico de alta qualidade para o avanço da nossa compreensão das doenças humanas e com o objetivo de melhorar a prevenção, o cuidado, o diagnóstico e o tratamento de pacientes em todo o mundo.
An alarming number of pandemics are affecting the world’s population, including viral infections, overweight/obesity, and metabolic disorders. Genetic variants may be involved in underlying mechanisms of lipid metabolism and intrahepatic fat accumulation. The minor allele frequencies (MAFs) of variants in the microsomal triglyceride transfer protein (MTTP) gene, which unbalance the concentration of cholesterol, low-density lipoprotein and apolipoprotein B,(–) were investigated in 241 healthy Brazilians.
[…]
Frequency of genetic variants involved in lipid metabolism and intrahepatic fat
MagriMC, PrataTVG, DantasBP, ManchieroC, FigueiredoGM, TenganFM. Frequency of genetic variants involved in lipid metabolism and intrahepatic fat. einstein (Sao Paulo). 2024;22:eCE1122. https://doi.org/10.31744/einstein_journal/2024CE1122
Magri,Mariana Cavalheiro; Prata,Thamiris Vaz Gago; Dantas,Bianca Peixoto; Manchiero,Caroline; Figueiredo,Gerusa Maria; Tengan,Fátima Mitiko. Frequency of genetic variants involved in lipid metabolism and intrahepatic fat. einstein (Sao Paulo)., v. 22, eCE1122, set. 2024. https://doi.org/10.31744/einstein_journal/2024CE1122
Magri,M.C., Prata,T.V.G., Dantas,B.P., Manchiero,C., Figueiredo,G.M., & Tengan,F.M. (2024). Frequency of genetic variants involved in lipid metabolism and intrahepatic fat. einstein (Sao Paulo).,22, eCE1122. https://doi.org/10.31744/einstein_journal/2024CE1122
Magri,Mariana Cavalheiro and Prata,Thamiris Vaz Gago and Dantas,Bianca Peixoto and Manchiero,Caroline and Figueiredo,Gerusa Maria and Tengan,Fátima Mitiko. Frequency of genetic variants involved in lipid metabolism and intrahepatic fat. einstein (Sao Paulo). [online]. 2024, vol. 22, [cited 2026-06-27], eCE1122. Available from: <https://journal.einstein.br/pt-br/article/frequency-of-genetic-variants-involved-in-lipid-metabolism-and-intrahepatic-fat/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2024CE1122
Figure 5
DNA triple helix (triplex) structures. A) Three-dimensional view of an intramolecular DNA triplex solved by solution-state nuclear magnetic resonance (PDB ID: 1BCB). The structure was deposited by Asensio et al. (1998) and classified as DNA without mutations.(20) This triple helical arrangement illustrates the association of a third strand with the canonical duplex, stabilized by Hoogsteen interactions. B) Simplified schematic (adapted from Brazda et al., 2020; and Holder et al., 2015) illustrating the principle of triplex formation.(22,23) The canonical duplex is stabilized by Watson–Crick base pairs, while the third strand binds in the major groove via Hoogsteen hydrogen bonds. The chemical structure shown in green corresponds to adenine from the third strand, forming a representative T·A·T triad with a Watson–Crick A·T base pair. Such alternative base-pairing interactions enable an additional strand to associate with duplex DNA through Hoogsteen hydrogen bonding, generating a triple-helical structure capable of modulating essential processes such as replication and transcription