A revista einstein (São Paulo) - e-ISSN 2317-6385 é dedicada à divulgação de conteúdo científico de alta qualidade para o avanço da nossa compreensão das doenças humanas e com o objetivo de melhorar a prevenção, o cuidado, o diagnóstico e o tratamento de pacientes em todo o mundo.
Moving towards an evidence-based education brings several challenges, including the underpinning foundations of current training. Simulation-based education (SBE) has been based on several rigorous research studies to demonstrate its efficacy. However, educators and researchers still use theories that are currently considered educational myths instead of theories with solid scientific evidence. In this editorial, we will describe several myths used in education and present theories that have been widely evidenced in the educational context. We hope this editorial will increase awareness of educators about educational myths and that they start using evidence-based theory in education.
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Debunking educational myths: towards evidence-based simulation training
Cecilio-Fernandes,Dario and Mazzo,Alessandra and Melo,Brena Carvalho Pinto de and Molina,Mariana Santos Alecrim and Hashimoto,Priscilla Cerullo and Silva,Joyce Kelly Barreto and Gonçalves,Desiree and Couto,Thomaz Bittencourt. Debunking educational myths: towards evidence-based simulation training. einstein (Sao Paulo). [online]. 2025, vol. 23, n. (Suppl 3), [cited 2026-06-26], eED0001. Available from: <https://journal.einstein.br/pt-br/article/debunking-educational-myths-towards-evidence-based-simulation-training/>. ISSN 1679-4508. https://doi.org/10.31744/einstein_journal/2025Suppl_3ED0001
Figure 5
DNA triple helix (triplex) structures. A) Three-dimensional view of an intramolecular DNA triplex solved by solution-state nuclear magnetic resonance (PDB ID: 1BCB). The structure was deposited by Asensio et al. (1998) and classified as DNA without mutations.(20) This triple helical arrangement illustrates the association of a third strand with the canonical duplex, stabilized by Hoogsteen interactions. B) Simplified schematic (adapted from Brazda et al., 2020; and Holder et al., 2015) illustrating the principle of triplex formation.(22,23) The canonical duplex is stabilized by Watson–Crick base pairs, while the third strand binds in the major groove via Hoogsteen hydrogen bonds. The chemical structure shown in green corresponds to adenine from the third strand, forming a representative T·A·T triad with a Watson–Crick A·T base pair. Such alternative base-pairing interactions enable an additional strand to associate with duplex DNA through Hoogsteen hydrogen bonding, generating a triple-helical structure capable of modulating essential processes such as replication and transcription