Highlights ■ In-house 68Ga radiopharmaceutical synthesis under GMP in a tertiary hospital radiopharmacy. ■ Over 7,500 patients underwent imaging with [68Ga]Ga-  DOTATATE and [68Ga]Ga-PSMA-11. ■ This is the first radiopharmacy in Brazil to introduce [68Ga] Ga-DOTA-UBI, and [68Ga]Ga-FAPi-46. ABSTRACT In this study, we report the implementation of in-house synthesis of gallium-68 (68Ga)-labeled radiopharmaceuticals for positron emission tomography (PET) at a tertiary hospital radiopharmacy. [68Ga]Ga-DOTATATE and [68Ga]Ga-PSMA-11 were introduced into clinical practice in January 2014 and October 2015, respectively, following the […]

ABSTRACT Molecular imaging markers can be used to differentiate between infection and aseptic inflammation, determine the severity of infection, and monitor treatment responses. One of these markers is ubiquicidin(29-41) (UBI), a cationic peptide fragment that binds to the bacterial membrane wall and is labeled with gallium-68 (68Ga), a positron emitter radioisotope. The use of UBI in positron emission tomography (PET)/computed tomography (CT) for improved detection of lesions has been receiving considerable attention recently. Herein, we report the first case of […]

RESUMO Objetivo Evidenciar a situação atual da Medicina Nuclear brasileira em relação à inovação, considerando a proteção à Propriedade Intelectual e suas particularidades na área. Métodos Foi realizado um levantamento comparativo do número e da origem de depósitos de patentes relacionadas a essa área no Brasil, nos Estados Unidos e em países participantes da European Patent Convention , em um período de 20 anos retroativos. Resultados O número de depósitos acumulados de patentes de medicamentos convencionais foi dez vezes maior […]