Einstein (São Paulo) invites submissions for a special issue exploring the broad Oral Health and Systemic Impact: a New Frontier of Care. This special issue seeks to consolidate high-quality evidence, clarify mechanisms, and accelerate translation into clinical and public health practice. Oral and systemic health are tightly interconnected through immune, microbial, metabolic, and vascular pathways. The traditional separation between dentistry and medicine is progressively untenable given converging evidence that chronic oral inflammation, microbial dysbiosis, and periodontal pathogens contribute to systemic disease processes and vice versa. The oral cavity functions as both a sentinel and a modulator of the whole body in both healthy and diseased conditions. Current data implicate oral conditions in the initiation and progression of cardiometabolic disorders, adverse pregnancy outcomes, and neuroinflammatory states, oncologic processes, among others.

We aim to move the field beyond association by prioritizing original manuscripts, systematic and narrative reviews that strengthen causal inference, delineate biological and behavioral mediators, and test interventions that improve patient-centered and health-system outcomes. Case reports that advance the field and offer novelty are welcome.

The goal is an integrated model of care in which oral health is embedded within chronic disease prevention and management, and dental professionals are core members of interdisciplinary teams, mainly in hospitals and care centers. We invite contributions that advance conceptual rigor, methodological precision, and clinical applicability.

These are the Scope and Priority Themes, but not limited to:

1) Mechanistic Pathways

2) Clinical and Epidemiological Evidence

3) Oral–Brain Axis

4) Cardiometabolic Health

5) Maternal and Fetal Health

6) Diagnostics and Therapeutics

7) Integrated Care and Policy

8) Oncologic Interactions with Oral Health

9) Laser-Based Strategies in Oncologic and Supportive Care

10) Palliative and Supportive Oral Care

Submission Guidelines
Article Types: We invite Editorial, Original Article, Health Economics and Management, Review, Case Report and Learning by Images.

Communications that critically explore the state of the art in HSCT. Manuscripts must adhere to the einstein (São Paulo) Instructions for Authors and will undergo peer review.

For any questions or pre-submission discussions on Reviews, authors are welcome to contact the editorial team. Submissions are accepted in English only.

Guest Editors: Leticia Bezinelli, Jamil Awad Shibli and Ricardo Santiago Gomez

Editors-in-Chief

Kenneth J. Gollob and Claudio R. Cernea