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Recent Articles

Red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells

Camila de Carvalho Juanes ORCID logo , Susana Moreira de Souza ORCID logo , Vanessa Nogueira Lages Braga ORCID logo , Francisco Stefânio Barreto ORCID logo , Gisele Rocha Aguiar ORCID logo , Kleison Douglas Gomes Pimentel ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4576

ABSTRACT Objective: To evaluate the effect of red propolis and L-lysine on angiogenesis and tumor growth in a new model of hamster cheek pouch inoculated with Walker 256 tumor cells. Methods: The study consisted of two experiments with four groups each (total: 57 hamsters). In the experiment 1, the animals were inoculated with Walker tumor cells, followed by administration of test substances (red propolis 200mg/5mL/kg or L-lysine 150mg/kg) or control substances (gum arabic 5mL/kg or water 5mL/kg) for 10 days. […]

Prospective randomized trial comparing radiofrequency ablation and complete saphenous vein stripping in patients with mild to moderate chronic venous disease with a 3-year follow-up

Igor Rafael Sincos ORCID logo , Anna Paula Weinhardt Baptista ORCID logo , Felipe Coelho Neto ORCID logo , Nicos Labropoulos ORCID logo , Luciane Basílio Alledi ORCID logo , Emmanuel Machado de Marins ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4526

ABSTRACT Objective: To compare the use of the radiofrequency thermoablation of the saphenous vein with the ligation technique, and complete removal of the saphenous vein, from the saphenofemoral junction to the ankle. Methods: A total of 49 patients with chronic venous disease in the Comprehensive Classification System for Chronic Venous Disorders (CEAP) classes 2 to 4 for clinical signs, etiology, anatomic distribution and pathophysiology, were assessed at baseline, after 4 weeks, and after 1 year. The parameters assessed were complications, […]

Most frequent errors in inhalation technique of patients with asthma treated at a tertiary care hospital

Carlos Leonardo Carvalho Pessôa ORCID logo , Maria Julia da Silva Mattos ORCID logo , Artur Renato Moura Alho ORCID logo , Marianna Martini Fischmann ORCID logo , Bruno Mendes Haerdy ORCID logo , Ana Carolina Castro Côrtes ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4397

ABSTRACT Objective: To demonstrate the most frequent errors in inhalation technique in patients with asthma undergoing treatment at a tertiary care hospital. Methods: A cross-sectional study with a convenience sample of asthma patients aged 18 years or over, treated at a pulmonology outpatient clinic of a tertiary care hospital. The assessment of inhalation technique of users of the dry powder inhalers Aerolizer®, Aerocaps and Diskus®, or metered-dose inhalers was based on the manufacturer’s instructions for use of each inhaler device. […]

Applicability of papain solutions in immunohematology

Laís Priscila De Santis ORCID logo , Patrícia Carvalho Garcia ORCID logo , Valéria Nogueira Dias Paes Secco ORCID logo , Rosana Rossi Ferreira ORCID logo , Elenice Deffune ORCID logo

DOI: 10.31744/einstein_journal/2019AO4328

ABSTRACT Objective: To compare the enzyme activity of different presentations of papain solution to validate in-house preparations. Methods: Two papain solutions were prepared, and the third presentation was a commercial solution. Tests were carried out with samples of red cells typed as weak RhD. Results: In-house prepared papain solutions showed similar enzyme reactivity, and statistically no differences compared to the enzyme activity of the commercial solution. Conclusion: Evaluating the cost-benefit ratio, the in-house prepared papain solutions present more economic advantages, […]

Urinary incontinence following subtotal and total hysterectomy: a systematic review

Priscila Scalabrin Longo ORCID logo , Laura Virilo Borbily ORCID logo , Felipe Placco Araujo Glina ORCID logo

DOI: 10.31744/einstein_journal/2019RW4320

ABSTRACT Objective: To evaluate the best surgical approach for the female urinary incontinence. Methods: Systematic review conducted in MEDLINE® Cochrane, EMBASE and LILACS database up to September 1st, 2017. Articles were selected according to study type, type of intervention and outcomes. Articles were selected by more than one researcher based on title, abstract and full text. The SIGN checklist was used for bias assessment. Results: A total of 165 articles were retrieved from MEDLINE® . Twenty-five studies were elected for […]

Assessment of clinical and epidemiological characteristics of patients with and without sepsis in intensive care units of a tertiary hospital

Luis Gustavo Morello ORCID logo , Líbera Maria Dalla-Costa ORCID logo , Rafael Mialski Fontana ORCID logo , Ana Cristina Schmidt de Oliveira Netto ORCID logo , Ricardo Rasmussen Petterle ORCID logo , Danieli Conte ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4476

ABSTRACT Objective To describe the clinical and epidemiological features of patients with and without sepsis at critical care units of a public hospital. Methods A cross-sectional study was carried out from May 2012 to April 2013. Clinical and laboratory data of patients with and without sepsis in the intensive care units were reviewed of medical records. Results We evaluated 466 patients, 58% were men, median age was 40 years, and 146 (31%) of them were diagnosed with sepsis. The overall […]

Experimental study for evaluation of a low-cost spray cryotherapy system

Altair da Silva Costa Jr ORCID logo , Andre Miotto ORCID logo , Gustavo Andrade de Paulo ORCID logo , Angelo Paulo Ferrari ORCID logo , Luiz Hirotoshi Ota ORCID logo

DOI: 10.31744/einstein_journal/2019AO4533

ABSTRACT Objective To evaluate the feasibility and applicability of a low-cost cryotherapy system. Methods Experimental study with 25kg Landrace pigs submitted to a longitudinal cervico-thoraco-abdominal incision for exposure of the trachea, thorax and abdomen. The tissues were frozen by continuous spray application at different periods of time (5, 10 and 15 seconds). Spray cryotherapy was performed using a fluorinated gas (tetrafluorethane) delivered at – 47°C temperature (DermaFreeze®, Emdutos; ANVISA registration 80409950001; price R$ 394,00). via an adapted, disposable 1.8mm cholangiography […]

Validity and reliability of the Health Literacy Assessment Scale for adherence to drug treatment among diabetics

Maria Clara Lélis Ramos Cardoso ORCID logo , Aline Soares Figueiredo Santos ORCID logo , Adélia Dayane Guimarães Fonseca ORCID logo , Renê Ferreira da Silva Junior ORCID logo , Priscilla Durães de Carvalho ORCID logo , Andrea Maria Eleutério de Barros Lima Martins ORCID logo

DOI: 10.31744/einstein_journal/2019AO4405

ABSTRACT Objective To prepare an instrument to evaluate health literacy with regard to adherence to drug treatment among diabetics, identify the validity of its content, and estimate its reliability. Methods Pilot study, with the following stages of instrument construction: literature review, content validation, reliability estimation (internal consistency/Cronbach’s alpha and reproducibility/Kappa). Results The validity of content was completed and presented alpha=0.77 and Kappa values ranged from 0.31 to 1.00. Conclusion The instrument was approved regarding content validity, presented acceptable internal consistency […]

Electrocardiographic changes in spondyloarthritis and use of anti-TNF-α drugs: a retrospective study with 100 patients

Betânia Longo ORCID logo , Luziel Andrei Kirchner ORCID logo , Juliana Simioni ORCID logo , Ana Paula Beckhauser de Campos ORCID logo , Thelma Larocca Skare ORCID logo

DOI: 10.31744/einstein_journal/2019AO4539

ABSTRACT Objective To investigate the prevalence of electrocardiographic changes in patients with spondyloarthritis and to correlate these changes with use of anti-tumor necrosis factor-alpha (TNF-α) drugs and HLA-B27 positivity. Methods Retrospective study including 100 patients diagnosed with spondyloarthritis according to Assessment of SpondyloArthritis International Society (ASAS) criteria and 50 controls. Epidemiological and clinical features, results of inflammatory activity tests, HLA-B27 positivity, and medication use data were extracted from medical records. Disease activity was assessed using the Bath Ankylosing Spondylitis Disease […]