Laboratory assay of ADAMS 13

ADAMS 13 is a metalloprotease responsible for cleavage of Von Willebrand ultra large multimers. Severe deficiency of this protease, either by auto-antibodies against it or by complement lead to severe thrombotic diseases, such as thrombotic thrombocytopenic purpura or hemolytic uremic syndrome. There are some evidences […]

Reducing hospital toxicity: impact on patient outcomes

Circadian rhythms are disrupted by routine hospital care. There is also a loss of personal control of health. This loss can lead to adverse outcomes. The authors evaluated 3,425 consecutive patients admitted to a medical-surgical unit with a control wing (n=2,240) and an intervention wing […]

Flouroquine use and risk of aortic aneurysm and dissection: nationwide cohort study

Using the excellent Swedish medical record system a study analyzed medical charts of all patients treated with fluoroquinone between July 2006 and December 2013. The study reported that within 60 days after fluorquinolone use the ratio of aortic aneurysm and dissection was 1.2 cases/1000 persons […]

Should you stop wearing neckties?- wearing a tight necktie reduces cerebral blood flow.

Deficits in flow are expected when jugular veins and carotid arteries are compressed. An evidence already exist that neckties increase intraocular pressure. To many professions, including  those from the medical field in the USA, neckties are part of the dress code. A study conducted at […]

Is there a way to have a better visualization during robotic procedures?

“[…]The intraoperative identification of certain anatomical structures because they are small or visually occult may be challenging. The development of minimally invasive surgery brought additional difficulties to identify these structures due to the lack of complete tactile sensitivity. A number of different forms of intraoperative […]

Recent biotechnological advances on gene therapy: a review

“[…] The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered […]

New way of knowing when a baby will be born

Noninvasive blood tests and ultrasound can give information about fetal development and gestational age, but they could not predict spontaneous preterm birth or delivery date. A study by Ngo et al., including 31 healthy pregnant women showed that the cell-free RNA transcripts in fetal liver and […]

New way of preventing malaria

Ivermectin is capable of killing insects in small concentrations, attainable in blood after oral ingestion. In Australia the use of ivermectin in bovidae as vermifugue led to ecological problems due to massive death of beetles that fed on cattle feces. The paper showed clearly that […]

Is physical activity related to arterial hypertension in adolescents?

“[…] This is a cross-sectional study with 6039 high school  (14 to 19 years) were physical activity data were collected using a questionnaire. “Physically inactive” were considered those who reported not to walk or ride a bicycle to and from school on any day of […]

Detection of cancer: biomarkers in the blood

A group of researchers from John Hopkins and other scientists from an international collaboration applied a cancer diagnostic test to 1,005 patients with non-metastatic cancer and compared them with 812 healthy controls. The authors designed a 61-amplicon panel of 16 gens to seek for cancer-associated mutation […]

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