HIV viral load and transmissibility of HIV infection: undetectable means non transmissible

Many evidences exist on undetectable HIV viral load – which means less than 200 genomic copies/ml signifies that a patient will not transmit infection to other person. This small. but powerful review article, insists that all persons with HIV should adhere to treatment and have […]

Change from intravenous to oral antibiotics is possible, even in cases of endocarditis or bone and joint infections

A study from Denmark by Iversen and colleagues that included 400 patients with left side endocarditis compared two groups. Their sample was composed by randomized patients who used the usual regimen of intravenous antibiotics for longer periods versus those who changed intravenous antibiotics to oral […]

Acute infection and myocardial infarction

The risk of myocardial infarction after infection is well known, and for inpatients with pneumococcal pneumonia, it is 7 to 8%. This risk is higher at the onset of infection, is proportional to severity of pneumonia, and persists for at least 5 weeks. The risk […]

Hard to treat multi-resistant gram negative bacteremia

First line antibiotics for gram negative bacteremia were defined as simultaneous to all carbapenems, all other beta lactams and all fluoroquinolones. In a sample including 173 American hospitals and 45,011 patients with gram negative bacteremia, a total of 471 (1%) had what the authors called difficult-to-treat […]

The future of Medicine in the time of artificial intelligence

A report published in The Lancet, Chilamkurthy et al report impressive results using deep learning to interpret critical findings on head CT scans. The sensitivity of the algorithms using artificial intelligence was compared to radiologists’ interpretation; specificity was a little – not much – less […]

Armadillos as vectors of Hansen’s disease

Zoonotic transmission of Mycobacterium leprae to humans by 9 banded armadillos was reported in the Southern United States of America, mainly in Texas, Louisiana and Florida. Armadillos’ meat are consumed in some areas of Brazil, including Para state.  This consumption includes a kind of ceviche using […]

Isolation time of patients with tuberculosis

One of the difficulties of managing tuberculosis in hospitalized patients is the maintenance of isolation time. The golden standard diagnostic test is culture negative for Mycobacterium tuberculosis. AFB stain can still be positive with non-viable bacteria, leading to more isolation time than necessary. The morphological […]

Laboratory assay of ADAMS 13

ADAMS 13 is a metalloprotease responsible for cleavage of Von Willebrand ultra large multimers. Severe deficiency of this protease, either by auto-antibodies against it or by complement lead to severe thrombotic diseases, such as thrombotic thrombocytopenic purpura or hemolytic uremic syndrome. There are some evidences […]

Reducing hospital toxicity: impact on patient outcomes

Circadian rhythms are disrupted by routine hospital care. There is also a loss of personal control of health. This loss can lead to adverse outcomes. The authors evaluated 3,425 consecutive patients admitted to a medical-surgical unit with a control wing (n=2,240) and an intervention wing […]

Flouroquine use and risk of aortic aneurysm and dissection: nationwide cohort study

Using the excellent Swedish medical record system a study analyzed medical charts of all patients treated with fluoroquinone between July 2006 and December 2013. The study reported that within 60 days after fluorquinolone use the ratio of aortic aneurysm and dissection was 1.2 cases/1000 persons […]

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