Flouroquine use and risk of aortic aneurysm and dissection: nationwide cohort study
Using the excellent Swedish medical record system a study analyzed medical charts of all patients treated with fluoroquinone between July 2006 and December 2013. The study reported that within 60 days after fluorquinolone use the ratio of aortic aneurysm and dissection was 1.2 cases/1000 persons compared to 0.7 cases/1000 persons who were amoxicillin users. The size of both samples was impressive: 360,088.00 fluoroquinone users (78 % ciprofloxacin) and 360,088.00 matched ampicillin users . The relative hazard risk for both aortic […]
Should you stop wearing neckties?- wearing a tight necktie reduces cerebral blood flow.
Deficits in flow are expected when jugular veins and carotid arteries are compressed. An evidence already exist that neckties increase intraocular pressure. To many professions, including those from the medical field in the USA, neckties are part of the dress code. A study conducted at Schleswig Holstein University, Kiel campus, included thirty volunteers who were divided into two groups: one wearing tight neckties and other without this “socially imposed semi-strangulation”. During a magnetic resonance imaging test and after tightening the […]
Is there a way to have a better visualization during robotic procedures?
“[…]The intraoperative identification of certain anatomical structures because they are small or visually occult may be challenging. The development of minimally invasive surgery brought additional difficulties to identify these structures due to the lack of complete tactile sensitivity. A number of different forms of intraoperative mapping have been tried. Recently, the near-infrared fluorescence imaging technology with indocyanine green has been added to robotic platforms. In addition, this technology has been tested in several types of operations, and has advantages such […]
Recent biotechnological advances on gene therapy: a review
“[…] The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered (mutated) genes or site-specific modifications that target therapeutic treatment. This therapy became possible through the advances of genetics and bioengineering that enabled manipulating vectors for delivery of extrachromosomal material to target cells. One of the […]
New way of knowing when a baby will be born
Noninvasive blood tests and ultrasound can give information about fetal development and gestational age, but they could not predict spontaneous preterm birth or delivery date. A study by Ngo et al., including 31 healthy pregnant women showed that the cell-free RNA transcripts in fetal liver and from placenta could evaluate the fetal development and identify possible delivery date better than calculations based on the patients’ last menstrual period. The small sample of the study did not allow extrapolation, therefore, further studies […]
New way of preventing malaria
Ivermectin is capable of killing insects in small concentrations, attainable in blood after oral ingestion. In Australia the use of ivermectin in bovidae as vermifugue led to ecological problems due to massive death of beetles that fed on cattle feces. The paper showed clearly that ivermectin with artemisin and piperaquine – the two last drugs with no activity against mosquitoes-, in doses higher than the usual for ivermectin (600 micrograms/k), increased the mortality of human-biting anopheles. No collateral effects were seen […]
Is physical activity related to arterial hypertension in adolescents?
“[…] This is a cross-sectional study with 6039 high school (14 to 19 years) were physical activity data were collected using a questionnaire. “Physically inactive” were considered those who reported not to walk or ride a bicycle to and from school on any day of the past week, and/or those who, regardless of the weekly frequency of practice this type of activity, reported the duration of commuting to school was less than 20 minutes (round trip). Adolescents with high blood […]
Detection of cancer: biomarkers in the blood
A group of researchers from John Hopkins and other scientists from an international collaboration applied a cancer diagnostic test to 1,005 patients with non-metastatic cancer and compared them with 812 healthy controls. The authors designed a 61-amplicon panel of 16 gens to seek for cancer-associated mutation of circulating cell-free DNA from plasma and evaluating 8 already known proteins, which present altered levels in individuals with cancer. Results using this algorithm to detect some cancer types were remarkable: almost 100% for colorectal […]
Impact of late radiation effects on cancer survivor children
“[…]Children survivors of cancer treatment were exposed to several late effects on adulthood, such as hypothyroidism, GH deficiency, obesity, diabetes mellitus, infertility, hearing loss, different organ dysfunctions, such as lung, heart, kidney and bladder, in addition to development of a second neoplasm. Thus, we emphasize the importance of early and regular follow-up of patients exposed to radiation during childhood, even at low doses, in order to enable diagnosis and treatment of these side effects, leading to better quality of life.” […]
Is smoking harmful to the adolescent heart?
“[…] To assess the association between cigarette smoking and ventricular arrhythmias in adolescents. Novel electrocardiographic parameters –Tp-e interval, as well as Tpe/QT and Tpe/QTc ratios – were used to make this assessment.” “[…] The study population consisted of 87 subjects aged between 16-19 years. Fifty-one adolescent smokers with no risk of arrhythmia comprised the Smoker Group, and 36 adolescents who had never smoked cigarettes comprised the Control Group.” “[…] Tp-e interval (98.4±12.7ms and 78.3±6.9 ms; p<0.001), Tpe/QT (0.28±0.04 and 22±0.03; […]