Volume 17, Number 1, 2019

Hormone receptor-negative as a predictive factor for pathologic complete response to neoadjuvant therapy in breast cancer

Luana Carolina Ferreira Fiuza Silva ORCID logo , Lilian Silva Martins de Arruda ORCID logo , Waldec Jorge David Filho ORCID logo , Felipe José Silva Melo Cruz ORCID logo , Damila Cristina Trufelli ORCID logo , Auro del Giglio ORCID logo

DOI: 10.31744/einstein_journal/2019AO3434

ABSTRACT Objective To define a predictive factor for pathologic complete response, compare the oncologic outcomes associated with the degree of pathologic response after neoadjuvant chemotherapy, and to analyze pathologic complete response as a prognostic factor for overall survival and progression-free survival. Methods A retrospective study of patients admitted to Hospital Estadual Mário Covas and Hospital Anchieta from 2008 to 2012, with locally advanced breast cancer. Hormone receptor status, HER2 status, histologic and nuclear grade, age upon diagnosis and histological type […]

Evaluation of the quality of Primary Health Care services for children: reflections on the feasibility of using the Brazilian version of the Primary Care Assessment Tool as a routine assessment tool

Liz Ponnet ORCID logo , Sara Willems ORCID logo , Veerle Vyncke ORCID logo , Aylene Emilia Moraes Bousquat ORCID logo , Ana Luiza d’Ávila Viana ORCID logo , Guilherme Arantes Mello ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4333

ABSTRACT Objective To assess the quality of the Primary Health Care services provided to children and the feasibility of using the Brazilian version of Primary Care Assessment Tool (PCAT-Brazil) as a routine quality assessment tool. Methods A cross-sectional study was carried out in Joanópolis, a small rural town in the State of São Paulo (SP), Brazil. Seven health professionals and 502 caretakers of children using the public health center were interviewed using the PCAT-Brazil, collecting data on the core and […]

Association between respiratory capacity, quality of life and cognitive function in elderly individuals

Rayana de Oliveira Costa ORCID logo , Raphael Mendes Ritti-Dias ORCID logo , Gabriel Grizzo Cucato ORCID logo , Maysa Seabra Cendoroglo ORCID logo , Fabio Nasri ORCID logo , Maria Luiza Monteiro Costa ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4337

ABSTRACT Objective To investigate associations between respiratory capacity, quality of life and cognitive function in elderly individuals. Methods The sample included 386 elderly individuals (232 women). Respiratory capacity assessment was based on maximal expiratory pressure measured at peak expiratory flow. Subjects were classified according to peak expiratory flow values adjusted for sex, age and height of individuals with normal (peak expiratory flow curve 60%) or reduced (peak expiratory flow curve < 60%) respiratory capacity. The World Health Organization Quality of [...]

Influence of parental smoking on the use of alcohol and illicit drugs among adolescents

Luciano Machado Ferreira Tenório de Oliveira ORCID logo , Ana Raquel Mendes dos Santos ORCID logo , Breno Quintella Farah ORCID logo , Raphael Mendes Ritti-Dias ORCID logo , Clara Maria Silvestre Monteiro de Freitas ORCID logo , Paula Rejane Beserra Diniz ORCID logo

DOI: 10.31744/einstein_journal/2019AO4377

ABSTRACT Objective: To evaluate the association between parental smoking and the use of alcohol and illicit drugs among adolescent children. Methods: A cross-sectional study with 6,264 adolescents (59.7% female) aged between 14 and 19 years. To establish the sample, we used two-stage cluster random sampling. The data on parental smoking and use of cigarettes, alcohol and illicit drugs among adolescents were collected using a questionnaire. Results: Smoking adolescents were more prone to use alcohol (odds ratio − OR: 10.35; 95%CI: […]

Effective vancomycin concentrations in children: a cross-sectional study

Geisa Cristina da Silva Alves ORCID logo , Farah Maria Drumond Chequer ORCID logo , Cristina Sanches ORCID logo

DOI: 10.31744/einstein_journal/2019AO4396

ABSTRACT Objective Analyze the microbiological effectiveness, based on the pharmacokinetics/pharmacodynamics correlation of vancomycin in pediatric patients, and to propose dose adjustment. Methods This is an observational, cross-sectional study, conducted in a pediatric hospital, over a 1-year period (2016 to 2017). Children of both sexes, aged 2 to 12 years, were included in the study; burn children, and children in renal replacement therapy were excluded. For the pharmacokinetic analysis, two samples of 2mL of whole blood were collected, respecting the 2-hour […]

Comparison of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in normoglycemic and hyperglycemic subjects

Brena Barros Mendes ORCID logo , Anniely Carvalho Rebouças Oliveira ORCID logo , Keila Correia de Alcântara ORCID logo

DOI: 10.31744/einstein_journal/2019AO4403

ABSTRACT Objective: To compare the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as possible parameters of systemic inflammation in hyperglycemic and normoglycemic subjects. Methods: A retrospective, cross-sectional study of data collected from patients tested for fasting blood glucose, glycated hemoglobin (HbA1c) and blood count on the same day, between July and December 2016. Patients were divided into hyperglycemic and normoglycemic, and matched by age and sex. The data were analyzed using Epi Info™, version 7.2.1.0, for the Windows® platform. Results: We enrolled 278 […]

When color helps

Ana Luiza Fontes de Azevedo Costa ORCID logo , Thiago Gonçalves dos Santos Martins ORCID logo , Ricardo Vieira Martins ORCID logo , Paulo Schor ORCID logo

DOI: 10.31744/einstein_journal/2019AO4410

ABSTRACT Objective: To reduce the inappropriate identification of eye drops, through the use of different colors. Methods: A group of 34 healthy volunteers was presented to two groups of four eye drops each. All eye drops were placed in identical, unlabelled vials. In one group, all four eye drops were transparent. In the other group, each had a different color. A number was assigned to each eye drop, and the volunteer was asked to identify it by color. We measured […]

Effects of overnight fasting on handgrip strength in inpatients

Wesley Santana Correa-Arruda ORCID logo , Iara dos Anjos Vaez ORCID logo , José Eduardo Aguilar-Nascimento ORCID logo , Diana Borges Dock-Nascimento ORCID logo

DOI: 10.31744/einstein_journal/2019AO4418

ABSTRACT Objective: To investigate the effects of overnight fasting on handgrip strength of adult inpatients. Methods: A prospective clinical study enrolling 221 adult patients. The endpoints were handgrip strength obtained by dynamometry in three time points (morning after an overnight fasting, after breakfast and after lunch) and the cumulative handgrip strength (mean of handgrip strength after breakfast and lunch) in the same day. The mean of three handgrip strength measures was considered to represent each time point. A cut-off for […]

Risk factors associated with in-hospital falls reported to the Patient Safety Commitee of a teaching hospital

Adriane Kênia Moreira Silva ORCID logo , Dayane Carlos Mota da Costa ORCID logo , Adriano Max Moreira Reis ORCID logo

DOI: 10.31744/einstein_journal/2019AO4432

ABSTRACT Objective To investigate the use of fall-risk-increasing drugs among patients with falls reported to the Patient Safety Office of a hospital, and to identify the factors associated with high risk for fall. Methods A cross-sectional study, carried out in a teaching hospital. The study population was the universe of fall reports received by the Patient Safety Office. The dependent variable was a high risk for falls. The Medication Fall Risk Score was used to measure fall risk. Descriptive, univariate […]

Prevalence of G6PD deficiency and molecular characterization of G202A, A376G and C563T polymorphisms in newborns in Southeastern Brazil

Lucas Luís Meigre Dias Pereira ORCID logo , Cristina Augusta Bravin ORCID logo , Terezinha Sarquis Cintra ORCID logo , Wélida Santos Portela Cassa ORCID logo , Thainá Altoé Santos ORCID logo , Armando Fonseca ORCID logo , [...]

DOI: 10.31744/einstein_journal/2019AO4436

ABSTRACT Objective To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays. Methods A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patients identified as deficient were submitted to molecular analysis quantitative real-time polymerase chain reaction – (qPCR) to investigate the presence of variants associated with the deficiency. Results The total prevalence of G6PD deficient was 2.5%. Of the 25 samples identified […]

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