Volume 16, Number 3, July/September 2018

Big Data use in medical research

Thiago Gonçalves dos Santos Martins ORCID logo , Ana Luiza Fontes de Azevedo Costa ORCID logo , Thomaz Gonçalves dos Santos Martins ORCID logo

DOI: 10.1590/S1679-45082018ED4087

The current velocity and volume of data generated by websites, electronic sensors and mobile telephones are calculated in exabytes (equal to 1 billion gigabytes) every two days. This amount of data corresponds to what was produced from the begining of the time until 2003. This remarkable figure tends to double every 40 months.() Big data is a huge set of data that exceeds management by human and requires assistance of computerized and/or analytical processing. Although the volume and velocity in […]

Latent tuberculosis infection and tuberculosis in children and adolescents

Cassia Satsuki Ishikawa ORCID logo , Olivia Mari Matsuo ORCID logo , Flavio Sarno ORCID logo

DOI: 10.1590/S1679-45082018AO4090

ABSTRACT Objective: To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. Methods: A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated with patient’s sex and diagnoses of tuberculosis and latent tuberculosis infection, χ2 or Fisher’s exact tests were used for qualitative variables, and Mann-Whitney test for quantitative or ordinal qualitative variables. Results: A total of 77 patients were evaluated. Age ranged from […]

Types and frequency of errors in the preparation and administration of drugs

Josiane Ribeiro Mendes ORCID logo , Maria Carolina Barbosa Teixeira Lopes ORCID logo , Cássia Regina Vancini-Campanharo ORCID logo , Meiry Fernanda Pinto Okuno ORCID logo , Ruth Ester Assayag Batista ORCID logo

DOI: 10.1590/S1679-45082018AO4146

ABSTRACT Objective: To identify compatibility, types and frequency of errors in preparation and administration of intravenous drugs. Methods: A cross-sectional and descriptive study performed at the emergency department of a university hospital in the city of São Paulo (SP). The sample consisted of 303 observations of the preparation and administration of intravenous drugs by nursing aides, nursing technicians and registered nurses, using a systematized script, similar to a checklist. The following variables were collected: errors related to dispensing, omission, schedule, […]

Human papillomavirus infection and cervical cancer precursor lesions in women living by Amazon rivers: investigation of relations with markers of oxidative stress

Bruna Emanuelle Sanches Borges ORCID logo , Elza Baia de Brito ORCID logo , Hellen Thais Fuzii ORCID logo , Cláudia Simone Baltazar ORCID logo , Aline Barreto Sá ORCID logo , Camile Irene Mota da Silva ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4190

ABSTRACT Objective To investigate the relation between oxidative stress markers, human papillomavirus infection and cervical cancer precursor lesions. Methods The study comprised women aged 14 to 60 years living in communities located by Amazon rivers in the state of Pará (Itaituba, Limoeiro do Ajuru and Bragança, 126, 68 and 43 women respectively). Papanicolau smears and polymerase chain reaction tests for human papillomavirus DNA detection were performed. Blood samples were collected to test malondialdehyde, total and oxidized glutathione levels. Results Malondialdehyde, […]

Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

Jhenifer Karvat ORCID logo , Camila Mayumi Martin Kakihata ORCID logo , Lizyana Vieira ORCID logo , José Luis da Conceição Silva ORCID logo , Lucinéia de Fátima Chasko Ribeiro ORCID logo , Rose Meire Costa Brancalhão ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4206

ABSTRACT Objective: To evaluate the effects of right sciatic nerve compression and cryotherapy on muscle tissue. Methods: We used 42 male Wistar rats, subdivided in the following Groups Control, Injury 3, Injury 8 and Injury 15 submitted to nerve compression and euthanized in the 3rd, 8th and 15th day after surgery. The Cryotherapy Injury 3 was entailed treatment with cryotherapy by immersion of the animal in recipient for 20 minutes during 1 day, then animals were euthanized at the 3rd […]

Intradetrusor onabotulinumtoxinA injections are significantly more efficacious than oral oxybutynin for treatment of neurogenic detrusor overactivity: results of a randomized, controlled, 24-week trial

Rúiter Silva Ferreira ORCID logo , Carlos Arturo Levi D’Ancona ORCID logo , Matthias Oelke ORCID logo , Maurício Rassi Carneiro ORCID logo

DOI: 10.1590/S1679-45082018AO4207

ABSTRACT Objective To prospectively compare the results of intradetrusor onabotulinumtoxinA injections and oral oxybutynin for urinary continence, urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity due to spinal cord injury. Methods Adult patients under intermittent catheterization were randomized 1:1 to receive one injection of onabotulinumtoxinA 300U or oxybutynin 5mg, per oris, three times/day. Primary study endpoint was change in urinary incontinence episodes/24 hours and secondary study endpoints were maximum cystometric capacity, maximum detrusor pressure, bladder compliance […]

Oral colonization by Candida species in HIV-positive patients: association and antifungal susceptibility study

Letícia Silveira Goulart ORCID logo , Werika Weryanne Rosa de Souza ORCID logo , Camila Aoyama Vieira ORCID logo , Janaina Sousa de Lima ORCID logo , Ricardo Alves de Olinda ORCID logo , Claudinéia de Araújo ORCID logo

DOI: 10.1590/S1679-45082018AO4224

ABSTRACT Objective To investigate antifungal susceptibility and factors associated with oral colonization by Candida species in HIV-positive patients. Methods A prospective study based on convenience sampling of subjects recruited from a pool of confirmed HIV-positive individuals seen at a specialty outpatient service in Rondonópolis, Mato Grosso, Brazil). Oral swabs were collected from 197 patients. Candida species were identified by standard microbiological techniques (phenotypic and molecular methods). Antifungal susceptibility was investigated using the broth microdilution method. Results A total of 101 […]

Profile of medical students in the first group of the Faculdade Israelita de Ciências da Saúde Albert Einstein

Ângela Tavares Paes ORCID logo , Bruna de Freitas Dias ORCID logo , Giulia Nicolucci Eleutério ORCID logo , Vitória Penido de Paula ORCID logo

DOI: 10.1590/S1679-45082018AO4228

ABSTRACT Objective: To describe first medical students’ profile of the Faculdade Israelita de Ciências da Saúde Albert Einstein. Methods: Data were collected using an electronic questionnaire during the Biostatistics course in August of 2016. The students were inquired about demographic characteristics, data on their secondary education and college entrance exams, practice of physical exercise, leisure activities done, to have a physician in the family, and specialty that they intended to pursue as a career. Results: Most of the students were […]

Fracture risk assessment in home care patients using the FRAX® tool

Vitor Moraes Rocha ORCID logo , Heloisa Amaral Gaspar ORCID logo , Claudio Flauzino de Oliveira ORCID logo

DOI: 10.1590/S1679-45082018AO4236

ABSTRACT Objective To assess the ten-year risk of hip and osteoporotic fracture in home care patients using the FRAX® tool. Methods A retrospective, cross-sectional observational study including patients aged ≥ 40 and ≤ 90 years and receiving home care from a private provider. The risk of fracture was calculated using an online calculator. High risk was defined as risk of hip fracture greater than 3% or risk of osteoporotic fracture greater than 20%. Data were expressed as absolute number (n), […]

Circumcision: postoperative complications that required reoperation

Carolina Talini ORCID logo , Letícia Alves Antunes ORCID logo , Bruna Cecília Neves de Carvalho ORCID logo , Karin Lucilda Schultz ORCID logo , Maria Helena Camargo Peralta Del Valle ORCID logo , Ayrton Alves Aranha Junior ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4241

ABSTRACT Objective To evaluate post-operative complications of circumcision requiring surgical reintervention. Methods Retrospective analysis of medical records of patients submitted to circumcision from May 1st, 2015 to May 31st, 2016. Results A total of 2,441 circumcisions were performed; in that, 1,940 using Plastibell and 501 by the classic technique. Complications requiring surgical reintervention were found in 3.27% of patients. When separated by surgical technique, 3.4% of circumcisions using Plastibell device required reoperation, as compared to 3% of conventional technique (p=0.79). […]

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