Volume 16, Number 3, July/September 2018

Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats

Gabriel Keine Kuga ORCID logo , Rafael Calais Gaspar ORCID logo , Vitor Rosetto Muñoz ORCID logo , Susana Castelo Branco Ramos Nakandakari ORCID logo , Leonardo Breda ORCID logo , Bruna Marina Sandoval ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4353

ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, […]

Oral colonization by Candida species in HIV-positive patients: association and antifungal susceptibility study

Letícia Silveira Goulart ORCID logo , Werika Weryanne Rosa de Souza ORCID logo , Camila Aoyama Vieira ORCID logo , Janaina Sousa de Lima ORCID logo , Ricardo Alves de Olinda ORCID logo , Claudinéia de Araújo ORCID logo

DOI: 10.1590/S1679-45082018AO4224

ABSTRACT Objective To investigate antifungal susceptibility and factors associated with oral colonization by Candida species in HIV-positive patients. Methods A prospective study based on convenience sampling of subjects recruited from a pool of confirmed HIV-positive individuals seen at a specialty outpatient service in Rondonópolis, Mato Grosso, Brazil). Oral swabs were collected from 197 patients. Candida species were identified by standard microbiological techniques (phenotypic and molecular methods). Antifungal susceptibility was investigated using the broth microdilution method. Results A total of 101 […]

Case-control study of oral disease indexes in individuals with head and neck cancer after antineoplastic therapy

Reyna Aguilar Quispe ORCID logo , Adrielle Lindolpho Cremonesi ORCID logo , Jeanne Kelly Gonçalves ORCID logo , Cassia Maria Fischer Rubira ORCID logo , Paulo Sérgio da Silva Santos ORCID logo

DOI: 10.1590/S1679-45082018AO4245

ABSTRACT Objective To evaluate the oral health of patients with head and neck cancer after antineoplastic treatment, and to compare them with patients with no history of cancer. Methods A total of 75 patients, divided into Study Group, composed of individuals after antineoplastic treatment (n=30), and Control Group, with individuals with no history of cancer (n=45), aged 37 to 79 years. The oral health status was evaluated through the index of decayed, missing or filled permanent teeth (DMFT), community periodontal […]

Intradetrusor onabotulinumtoxinA injections are significantly more efficacious than oral oxybutynin for treatment of neurogenic detrusor overactivity: results of a randomized, controlled, 24-week trial

Rúiter Silva Ferreira ORCID logo , Carlos Arturo Levi D’Ancona ORCID logo , Matthias Oelke ORCID logo , Maurício Rassi Carneiro ORCID logo

DOI: 10.1590/S1679-45082018AO4207

ABSTRACT Objective To prospectively compare the results of intradetrusor onabotulinumtoxinA injections and oral oxybutynin for urinary continence, urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity due to spinal cord injury. Methods Adult patients under intermittent catheterization were randomized 1:1 to receive one injection of onabotulinumtoxinA 300U or oxybutynin 5mg, per oris, three times/day. Primary study endpoint was change in urinary incontinence episodes/24 hours and secondary study endpoints were maximum cystometric capacity, maximum detrusor pressure, bladder compliance […]

Analysis of the indicators of the Family Health Program in the Metropolitan Region of São Paulo

Paulo Augusto Monteclaro Cesar ORCID logo , Márcia Mello Costa De Liberal ORCID logo , Valdecir Marvulle ORCID logo , Paola Zucchi ORCID logo

DOI: 10.1590/S1679-45082018GS4174

ABSTRACT Objective To analyze the Family Health Program replaced by the Family Health Strategy in 2011, based on health indicators and diseases classified as primary care sensitive. Methods This was a descriptive, analytical and documental study carried out in the Metropolitan Region of São Paulo between 2002 and 2007. We analyzed data from Health observatory for the Metropolitan Region of São Paulo. Pearson’s correlation and the Statistical Package for the Social Sciences software version 17.0 were used to calculate data […]

Trends in surgical treatment of femoral neck fractures in the elderly

Eva Jolanda Irene Lehtonen ORCID logo , Robert Davis Stibolt Jr ORCID logo , Walter Smith ORCID logo , Bradley Wills ORCID logo , Martim Correia Pinto ORCID logo , Gerald McGwin Jr ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4351

ABSTRACT Objective To analyze recent demographic and medical billing trends in treatment of femoral neck fracture of American elderly patients. Methods The American College of Surgeons National Surgical Quality Improvement Program database was analyzed from 2006 to 2015, for patients aged 65 years and older, using the Current Procedural Terminology codes 27130, 27125, 27235, and 27236. Patient demographics, postoperative complications, and frequency of codes were compared and analyzed over time. Our sample had 17,122 elderly patients, in that, 70% were […]

Fracture risk assessment in home care patients using the FRAX® tool

Vitor Moraes Rocha ORCID logo , Heloisa Amaral Gaspar ORCID logo , Claudio Flauzino de Oliveira ORCID logo

DOI: 10.1590/S1679-45082018AO4236

ABSTRACT Objective To assess the ten-year risk of hip and osteoporotic fracture in home care patients using the FRAX® tool. Methods A retrospective, cross-sectional observational study including patients aged ≥ 40 and ≤ 90 years and receiving home care from a private provider. The risk of fracture was calculated using an online calculator. High risk was defined as risk of hip fracture greater than 3% or risk of osteoporotic fracture greater than 20%. Data were expressed as absolute number (n), […]

Temporomandibular joint disorders as the only manifestation of juvenile idiopathic arthritis: a case report

José Renato Ribeiro Pinto ORCID logo , Irineu Gregnanin Pedron ORCID logo , Estevam Rubens Utumi ORCID logo , Milton Edson Miranda ORCID logo , Elisa Cruz Pereira Pinto ORCID logo , Leopoldo Penteado Nucci ORCID logo

DOI: 10.1590/S1679-45082018RC4003

ABSTRACT Juvenile idiopathic arthritis is a term used to include all chronic childhood arthritis of unknown etiology. It is characterized by chronic inflammation persisting for at least 6 weeks, beginning before 16 years of age. The characteristics present are chronic synovitis, arthralgia, impaired joint mobility in at least one joint, and erosion with destruction of cartilage and subchondral bone, that could be associated or not with systemic involvement, according to each subtype of the disease. During the pathologic process, the […]

Analysis of the muscle tissue of Wistar rats submitted to the sciatic nerve compression model and cryotherapy

Jhenifer Karvat ORCID logo , Camila Mayumi Martin Kakihata ORCID logo , Lizyana Vieira ORCID logo , José Luis da Conceição Silva ORCID logo , Lucinéia de Fátima Chasko Ribeiro ORCID logo , Rose Meire Costa Brancalhão ORCID logo , [...]

DOI: 10.1590/S1679-45082018AO4206

ABSTRACT Objective: To evaluate the effects of right sciatic nerve compression and cryotherapy on muscle tissue. Methods: We used 42 male Wistar rats, subdivided in the following Groups Control, Injury 3, Injury 8 and Injury 15 submitted to nerve compression and euthanized in the 3rd, 8th and 15th day after surgery. The Cryotherapy Injury 3 was entailed treatment with cryotherapy by immersion of the animal in recipient for 20 minutes during 1 day, then animals were euthanized at the 3rd […]

Partnership for productive development of biosimilar products: perspectives of access to biological products in the Brazilian market

Morton Aaron Scheinberg ORCID logo , Paulo Antonio Oldani Felix ORCID logo , Igor Age Kos ORCID logo , Maurício De Angelo Andrade ORCID logo , Valderilio Feijó Azevedo ORCID logo

DOI: 10.1590/S1679-45082018RW4175

ABSTRACT The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products. […]

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