Volume 15, Number 3, July/September 2017

The therapeutic challenge of giant splenic artery aneurysm: a case repport

Paulo Kauffman, Antonio Luiz de Vasconcellos Macedo, Roberto Sacilotto, Adriano Tachibana, Sergio Kuzniec, Lucas Lembrança Pinheiro, [...]

DOI: 10.1590/S1679-45082017RC3873

ABSTRACT Giant splenic artery aneurysm is a rare condition that represents an eminent life threatening for the patient, requiring, therefore, urgent surgical correction. A 61-year-old woman, former smoker, hypertensive, hypercholesterolemic and multipara sought our service because of a large tumor in the mesogastrium, which was an abdominal ultrasound finding. Despite the size of the tumor, the patient was asymptomatic. The angiotomography and the magnetic resonance image of the abdomen were suggestive of giant splenic artery aneurysm with more than 10cm […]

Successful treatment of post-transplant relapsed acute myeloid leukemia with FLT3 internal tandem duplication using the combination of induction chemotherapy, donor lymphocyte infusion, sorafenib and azacitidine. Report of three cases

Paulo Vidal Campregher, Vinicius Renan Pinto de Mattos, Marco Aurélio Salvino, Fabio Pires de Souza Santos, Nelson Hamerschlak

DOI: 10.1590/S1679-45082017RC3784

ABSTRACT Acute myeloid leukemia is a hematopoietic stem cell neoplastic disease associated with high morbidity and mortality. The presence of FLT3 internal tandem duplication mutations leads to high rates of relapse and decreased overall survival. Patients with FLT3 internal tandem duplication are normally treated with hematopoietic stem cell transplantation in first complete remission. Nevertheless, the incidence of post-transplant relapse is considerable in this group of patients, and the management of this clinical condition is challenging. The report describes the outcomes […]

Mediastinal tumor: not always a lymphoma

Silvia Mansur Reimão, Rogério Colaiacovo, Marco Antonio Ribeiro Camunha, Thiago Trolez Amancio, Vanderlei Segatelli, Gustavo Andrade de Paulo

DOI: 10.1590/S1679-45082017AI3981

A 45-year-old male patient, hospitalized and under investigation of mediastinal mass, presenting with sudoresis, malaise, and dysphagia. Computed tomography showed eccentric parietal thickening of the middle third of esophagus, with mass effect and upstream ectasia, with no expressive increase of metabolic activity. Additionally, there are cervical, axillary, pulmonary hilar, portocaval space, and unspecific iliac lymph nodes ( and ). […]

Endoscopic surveillance of extensive esophageal papillomatosis not amenable to endoscopic therapy

Angelo Paulo Ferrari, Fernanda Prata Martins

DOI: 10.1590/S1679-45082017RC3905

ABSTRACT We present two cases of esophageal papillomatosis, a very rare reported disease leading to dysphagia and did not improve after endoscopic treatment. Both patients refused surgery and they were followed-up for 3 years, but no significant clinical or endoscopic changes were seen.

New US Preventive Service Task Force recommendations for prostate cancer screening: a needed update, but not enough

Marcelo Langer Wroclawski

DOI: 10.1590/S1679-45082017ED4151

Prostate cancer (PC) screening remains a controversial topic, although it has been studied for more than two decades. Since the 1990s, when the use of Prostate-Specific Antigen (PSA) began in clinical practice, the mortality rate from PC has decreased by around 50%. Prostate cancer screening policies, early diagnosis and treatment are pointed out as responsible to 45%-70% of this reduction.() On the other hand, indiscriminate screening can lead to problems because of unnecessary prostate biopsies, and their possible side effects, […]


Jacyr Pasternak

DOI: 10.1590/S1679-45082017ED4239

We all are amazed by the extent of corruption in our political system. We believe corruption is frequent or even the norm, such as to receive money from private construction companies that build for the government, exchanging favors and money for politicians. As an excuse, some entrepreneurs declared that without these favors they would never get the contracts… The corrupted politicians said that without the money given by these companies, they would be unable to pay for their election campaigns, […]

The effects of cigarette smoking on ventricular repolarization in adolescents

Seyma Kayali, Fadime Demir

DOI: 10.1590/S1679-45082017AO3945

ABSTRACT Objective To assess the association between cigarette smoking and ventricular arrhythmias in adolescents. Novel electrocardiographic parameters –Tp-e interval, as well as Tpe/QT and Tpe/QTc ratios – were used to make this assessment. Methods The study population consisted of 87 subjects aged between 16-19 years. Fifty-one adolescent smokers with no risk of arrhythmia comprised the Smoker Group, and 36 adolescents who had never smoked cigarettes comprised the Control Group. Smokers were defined as patients smoking more than three cigarettes per […]

Analysis of colostrum IgA against bacteria involved in neonatal infections

Elizabeth Moreira Dias, Denise Bertulucci Rocha Rodrigues, Vinícius Rangel Geraldo-Martins, Ruchele Dias Nogueira

DOI: 10.1590/S1679-45082017AO3958

ABSTRACT Objective To describe e compare the specificity of IgA antibodies against bacteria extract of Klebsiella pneumoniae , Staphylococcus aureus , Escherichia coli , and Salmonella enteritidis . Methods Colostrum samples were aseptically collected in the first 12 hours after C-section delivery. The specificity of IgA against bacteria extracts was analyzed by the Western blot. Results The findings showed proteins of high molecular weight frequently detectable in the samples. S. aureus was the most frequently found bacterium in the samples […]

Static and dynamic balance of children and adolescents with sensorineural hearing loss

Renato de Souza Melo, Sônia Elvira dos Santos Marinho, Maryelly Evelly Araújo Freire, Robson Arruda Souza, Hélio Anderson Melo Damasceno, Maria Cristina Falcão Raposo

DOI: 10.1590/S1679-45082017AO3976

ABSTRACT Objective To assess the static and dynamic balance performance of students with normal hearing and with sensorineural hearing loss. Methods A cross-sectional study assessing 96 students, 48 with normal hearing and 48 with sensorineural hearing loss of both sexes, aged 7 and 18 years. To evaluate static balance, Romberg, Romberg-Barré and Fournier tests were used; and for the dynamic balance, we applied the Unterberger test. Results Hearing loss students showed more changes in static and dynamic balance as compared […]

How polymorphic markers contribute to genetic diseases in different populations? The study of inhibin A for premature ovarian insufficiency

Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, [...]

DOI: 10.1590/S1679-45082017AO4052

ABSTRACT Objective To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. Methods A 5mL sample of peripheral blood was collected from all study participants in an EDTA tube and was used for DNA extraction. For the patient group, 5mL of blood were also collected in a tube containing heparin for karyotype, and 5mL were collected in a dry […]

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