Volume 15, Number 1, January/March 2017

Precision Medicine

João Renato Rebello Pinho

DOI: 10.1590/S1679-45082017ED4016

Precision Medicine, Personalized Medicine, and Individualized Medicine (and even older terms, such as pharmacogenomics or pharmacogenetics) have often been used over the last years to mean the use of biological markers (obtained by ordering a few supplementary tests by physicians) that may indicate particular genetic characteristics of the different affected individuals and of the various diseases that affect them (such as genetic, oncologic, or infectious diseases). These biomarkers may be used to indicate the most adequate treatment and follow-up for […]

II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies

Ekaterini Simões Goudouris, Almerinda Maria do Rego Silva, Aluce Loureiro Ouricuri, Anete Sevciovic Grumach, Antonio Condino Neto, Beatriz Tavares Costa-Carvalho, [...]

DOI: 10.1590/S1679-45082017AE3844

ABSTRACT In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published […]

Interictal abnormal fMRI activation of visual areas during a motor task cued by visual stimuli in migraine

Adriana Bastos Conforto, Khallil Taverna Chaim, Mario Fernando Prieto Peres, André Leite Gonçalves, Inara Laurindo Siqueira, Maria Angela Maramaldo Barreiros, [...]

DOI: 10.1590/S1679-45082017AO3719

ABSTRACT Objective To assess changes in blood-oxygen-level-dependent activity after light deprivation compared to regular light exposure in subjects with migraine in the interictal state and in controls. Methods Ten subjects with migraine and ten controls participated in two sessions of functional magnetic resonance imaging. In each session, they performed a finger-tapping task with the right hand, cued by visual stimuli. They were scanned before and after 30 minutes of light deprivation or light exposure. In subjects with migraine, functional magnetic […]

Effects of zinc supplementation on fatigue and quality of life in patients with colorectal cancer

Sofia Miranda de Figueiredo Ribeiro, Camila Bitu Moreno Braga, Fernanda Maris Peria, Edson Zangiacomi Martinez, José Joaquim Ribeiro da Rocha, Selma Freire Carvalho Cunha

DOI: 10.1590/S1679-45082017AO3830

ABSTRACT Objective To investigate the effects of oral zinc supplementation on fatigue intensity and quality of life of patients during chemotherapy for colorectal cancer. Methods A prospective, randomized, double-blinded, placebo-controlled study was conducted with 24 patients on chemotherapy for colorectal adenocarcinoma in a tertiary care public hospital. The study patients received zinc capsules 35mg (Zinc Group, n=10) or placebo (Placebo Group, n=14) orally, twice daily (70mg/day), for 16 weeks, from the immediate postoperative period to the fourth chemotherapy cycle. Approximately […]

Blood pressure documentation in the emergency department

Ana Carolina Queiroz Godoy Daniel, Juliana Pereira Machado, Eugenia Velludo Veiga

DOI: 10.1590/S1679-45082017AO3737

ABSTRACT Objective To analyze the frequency of blood pressure documentation performed by nursing professionals in an emergency department. Methods This is a cross-sectional, observational, descriptive, and analytical study, which included medical records of adult patients admitted to the observation ward of an emergency department, between March and May 2014. Data were obtained through a collection instrument divided into three parts: patient identification, triage data, and blood pressure documentation. For statistical analysis, Pearson’s correlation coefficient was used, with a significance level […]

Performance of the dipstick screening test as a predictor of negative urine culture

Alexandre Gimenes Marques, André Mario Doi, Jacyr Pasternak, Márcio dos Santos Damascena, Carolina Nunes França, Marinês Dalla Valle Martino

DOI: 10.1590/S1679-45082017AO3936

ABSTRACT Objective To investigate whether the urine dipstick screening test can be used to predict urine culture results. Methods A retrospective study conducted between January and December 2014 based on data from 8,587 patients with a medical order for urine dipstick test, urine sediment analysis and urine culture. Sensitivity, specificity, positive and negative predictive values were determined and ROC curve analysis was performed. Results The percentage of positive cultures was 17.5%. Nitrite had 28% sensitivity and 99% specificity, with positive […]

Civil liability of the ophthalmologist in the São Paulo Court of Appeals

Isabel de Fátima Alvim Braga, Kelly de Oliveira Vieira, Thiago Gonçalves dos Santos Martins

DOI: 10.1590/S1679-45082017AO3781

ABSTRACT Objective To conduct a data survey on the subject of medical claims involving civil liability in ophthalmology at the São Paulo Court of Appeals. Methods A case law research was carried out on the São Paulo Court of Appeals website searching for the keyword “ophthalmologist” for all years until 2016. Results Of the 65 cases found, 29 were selected. There has been an increase in the number of claims in ophthalmology, especially in surgical procedures on the anterior chamber […]

Hypertension in patients admitted to clinical units at university hospital: post-discharge evaluation rated by telephone

Cássia Lima de Campos, Angela Maria Geraldo Pierin, Natalia Alencar de Pinho

DOI: 10.1590/S1679-45082017AO3862

ABSTRACT Objective To characterize hypertensive patients after admission to hospital considering the current status, compliance to treatment, habits and lifestyle, and knowledge and beliefs about the disease. Methods This was an exploratory study with 265 hypertensive patients admitted to a medical inpatients unit of a university hospital. Data were collected in an interview over the telephone. The level of significance was set as p

Patient safety: knowledge between multiprofessional residents

João Lucas Campos de Oliveira, Simone Viana da Silva, Pamela Regina dos Santos, Laura Misue Matsuda, Nelsi Salete Tonini, Anair Lazzari Nicola

DOI: 10.1590/S1679-45082017AO3871

ABSTRACT Objective To assess the knowledge of multiprofesional residents in health about the security of the patient theme. Methods Cross-sectional study, quantitative, developed with graduate courses/residence specialties of health in a public university of Paraná, Brazil. Participants (n=78) answered a questionnaire containing nine objective questions related to patient safety. Data were analyzed using descriptive statistics, in proportion measures. The minimum 75% of correct answers was considered the cutoff for positive evaluation. Results The sample was predominantly composed of young people […]

Depression and anxiety in a case series of amyotrophic lateral sclerosis: frequency and association with clinical features

Laura de Godoy Rousseff Prado, Isabella Carolina Santos Bicalho, Mauro Vidigal-Lopes, Vitor de Godoy Rousseff Prado, Rodrigo Santiago Gomez, Leonardo Cruz de Souza, [...]

DOI: 10.1590/S1679-45082017AO3870

ABSTRACT Objective To investigate the frequency of anxiety and depression and their association with clinical features of amyotrophic lateral sclerosis. Methods This is a cross-sectional and descriptive study including a consecutive series of patients with sporadic amyotrophic lateral sclerosis according to Awaji’s criteria. Patients underwent clinical and psychiatric assessment (anxiety and depression symptoms). Results We included 76 patients. The men/women ratio was 1.6:1. Participants’ mean age at disease onset was 55 years (SD±12.1). Sixty-six patients (86.8%) were able to complete […]

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