Volume 10, Number 3, July/September 2012

einstein: ten years

Sidney Glina

DOI: 10.1590/S1679-45082012000300002

Comparative analysis of gestations and frequency of prematurity and low birth weight among children of adolescent and adult mothers

Maria Isabel Naliato Perez Neto, Conceição Aparecida de Mattos Segre

DOI: 10.1590/S1679-45082012000300003

Objective:To perform a comparative analysis between the frequency of prematurity and low birth weight among newborns of adolescent and adult mothers, and to evaluate selected maternal data.METHODS:A comparative cohort study involving 703 pregnant women and their newborns at a public hospital in the city of São Paulo (270 mothers aged 10-19 years, and 433 aged 20-35 years), during the period from March to August 2003.RESULTS:The birth of premature or low birth weight children was not prominent in any of the […]

The MELD system and liver transplant waiting-list mortality in developing countries: lessons learned from São Paulo, Brazil

Paolo Salvalaggio, Rogerio Carballo Afonso, Luiz Augusto Pereira, Ben-Hur Ferraz-Neto

DOI: 10.1590/S1679-45082012000300004

Objective:The MELD system has not yet been tested as an allocation tool for liver transplantation in the developing countries. In 2006, MELD (Model for End-stage Liver Disease) was launched as a new liver allocation system in São Paulo, Brazil. This study was designed to assess the results of the new allocation policy on waiting list mortality.METHODS:The State of São Paulo liver transplant database was retrospectively reviewed from July 2003 through July 2009. Patients were divided into those who were transplanted […]

The detection of KIT mutations in acute myeloid leukemia

Luis Eduardo Silva Machado, João Renato Rebello Pinho, Roberta Sitnik, Nair Hideko Muto, Elvira Deolinda Rodrigues Pereira Velloso, Roberta Cardoso Petroni, [...]

DOI: 10.1590/S1679-45082012000300005

Objective:This study describes a new method used in the clinical laboratory at Hospital Israelita Albert Einstein to detect mutations in exons 8 and 17 of the KIT gene in patients with acute myeloid leukemia.METHODS:Genomic DNA extraction was performed on 54 samples of peripheral blood or bone marrow from patients with acute myeloid leukemia. The extracted DNA was amplified by polymerase chain reaction and sequenced, and the fragments were analyzed.RESULTS:Within the analyzed samples, we detected four mutations in exon 8, two […]

Interventional procedures for cancer pain management

Fabiola Peixoto Minson, Fabrício Dias Assis, Thais Kfouri Vanetti, Jamir Sardá Junior, Wanessa Pereira Mateus, Auro Del Giglio

DOI: 10.1590/S1679-45082012000300006

Objective:To describe types of interventional medical procedures its rationale use and benefits for a population with cancer assisted at a private hospital in São Paulo.METHODS:Quantitative and descriptive cross-sectional study using data from patients submitted to interventional procedures between 2007 and 2008. We used descriptive and inferential statistics (frequency, mean, and t-test) to analyze data.RESULTS:A total of 137 patients were submitted to interventional procedures for pain and, out of this total, 14 mentioned cancer-related pain. The mean pain intensity was 7.1 […]

Isolation and characterization of mesenchymal stem cells obtained from reusable and disposable bone marrow collection filters

Glaziane Cordeiro de Deus, Marilia Normanton, Nelson Hamerschlak, Andrea Tiemi Kondo, Andreza Alice Feitosa Ribeiro, Anna Carla Goldberg, [...]

DOI: 10.1590/S1679-45082012000300007

Objective:To compare human mesenchymal stem cells obtained from reusable and disposable filters and to characterize them according to the criteria of the International Society of Cellular Therapy.METHODS:Human mesenchymal stem cells were isolated from bone marrow collection reusable sets and compared with those obtained from disposable sets by washing the filters with cell culture media. The isolated cells were characterized according to the criteria of the International Society of Cellular Therapy using flow cytometry, differentiation in vitro, and cytochemistry techniques.RESULTS:Samples were […]

Analysis of transplant rejection in rabbits aponeurosis

Andre Ibrahim David, Eduardo Sauerbronn Gouvea, Felipe Ribeiro Batista, Paulo Henrique Fogaça de Barros, Dino Martini Filho, Victor Arias, [...]

DOI: 10.1590/S1679-45082012000300008

Objective:To study the feasibility of heterologous aponeurosis to close the abdominal wall of rabbits emphasizing the rejection process.METHODS:This project was approved by the Animals Care Committee of the Faculdade de Ciências Médicas da Santa Casa de São Paulo, and it was carried out at the Experimental Surgery and Technical Unit. Four red female rabbits exchanged abdominal wall aponeurosis with other four white male animals. Two rabbits just had it removed and replaced to be the control group for the healing […]

Pandemic influenza A/H1N1: comparative analysis of microscopic lung histopathological findings

Roberta Marchiori, Carla Sakuma de Oliveira Bredt, Marcos Menezes Freitas de Campos, Fábio Negretti, Péricles Almeida Delfino Duarte

DOI: 10.1590/S1679-45082012000300009

Objective:To analyze the histopathological lung findings of four fatal cases of the 2009 H1N1 influenza pandemic and their correlation with clinical and epidemiological characteristics.METHODS:Descriptive data from medical records of four patients who died in the Intensive Care Unit of a university hospital in 2009. Nasopharyngeal aspirate specimens were collected from the patients and were analyzed by real-time polymerase chain reaction. Lung biopsy was performed post mortem; a score of intensity for pathological changes was applied.RESULTS:Three patients had positive real-time polymerase […]

Factors associated with acute medication overuse in chronic migraine patients

Vera Zukerman Guendler, Juliane Prieto Peres Mercante, Reinaldo Teixeira Ribeiro, Eliova Zukerman, Mario Fernando Prieto Peres

DOI: 10.1590/S1679-45082012000300010

Objective:To evaluate the prevalence of psychiatric disorders in patients diagnosed with chronic migraine with and without acute medication overuse.METHODS:Seventy-two volunteers were recruited from a Family Health Program of the Paraisópolis community in São Paulo (SP), Brazil. These patients were submitted to a detailed headache questionnaire. All participants were submitted to physical and neurological examinations. The following variables were analyzed: age, gender, education level, body mass index, type of overused medication, headache characteristics, and caffeine consumption, lifetime anxiety and mood disorders.RESULTS:Out […]

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