Volume 9, Number 2 Pt 1, April/June 2011

Autologous stem-cell transplantation for multiple myeloma: a Brazilian institution experience in 15 years of follow-up

Juliana Todaro, Ana Rita de Araújo Burgos Manhani, José Mauro Kutner, Andreza Alice Feitosa Ribeiro, Morgani Rodrigues, Fabio Rodrigues Kerbauy, [...]

DOI: 10.1590/S1679-45082011AO1845

ABSTRACT Objective: To determine the 5-year post-transplant survival of patients with multiple myeloma. Methods: A retrospective study in patients diagnosed with multiple myeloma submitted to autologous bone marrow transplantation at a Brazilian institution, during the period of 1993 to 2007. Results: Seventy-three patients were evaluated with a median age of 55 years. Survival in 5 years was 75% (2.4 to 60 months). Statistical analysis demonstrated statistical significance for the applied grade of response prior to treatment with autologous bone marrow […]

Autologous stem-cell transplantation in Hodgkin’s lymphoma: analysis of a therapeutic option

Adriano de Moraes Arantes, Frederico Saddi Teixeira, Tathiana Maia Al Ribaie, Luciana Lobo Duartec, Cláudia Regina Abreu Silva, César Bariani

DOI: 10.1590/S1679-45082011AO1847

ABSTRACT Objective: To report the clinical progress of patients with Hodgkin’s lymphoma treated with autologous transplantation after failure or relapse of first-line treatment with chemotherapy and/or radiation therapy. Methods: The results of a retrospective analysis of 31 patients submitted to autologous transplantation as second-line treatment, between April 2000 and December 2008, were analyzed. Fourteen men and seventeen women, with a median age of 27 years, were submitted to autologous transplantation for relapsed (n = 21) or refractory (n = 10) […]

Thrombocytopenia: diagnosis with flow cytometry and antiplatelet antibodies

João Carlos de Campos Guerra, Ruth Hissae Kanayama, Sonia Tsukasa Nozawa, Márcia Regina Ioshida, Irina Yoko Takiri, Robson José Lazaro, [...]

DOI: 10.1590/S1679-45082011AO1846

ABSTRACT Objective: To identify antiplatelet antibodies by flow cytometry (direct method) in patients with thrombocytopenia. Methods: Between January 1997 and March 2004 a total of 15100 patients were referred to the Centro de Hematologia de São Paulo for hematological investigation of several diagnoses (anemia, leukopenia, thrombocytopenia, coagulation abnormalities, adenomegaly, leukemia and others). Of those, 1057 were referred because of thrombocytopenia and were divided into two groups: Group Idiopathic thrombocytopenic purpura, with no identifiable cause; and Group Other thrombocytopenia, which included […]

Red blood cell transfusion practice in a Pediatric Intensive Care Unit

Cibele Mendes, Dafne Cardoso Bourguignon da Silva, Rodrigo Genaro Arduini, Eduardo Juan Troster

DOI: 10.1590/S1679-45082011AO1884

ABSTRACT Objectives: To describe a population of children that received red blood cell transfusions. Methods: A retrospective observational study carried out at the Pediatric Intensive Care Unit of the Instituto da Criança of Hospital das Clínicas of Faculdade de Medicina of Universidade de São Paulo in 2004, with children that received red blood cell transfusions. Results: Transfusion of red blood cells was performed in 50% of the patients hospitalized. Median age was 18 months, and the primary motive for admission […]

Allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies: Hospital Israelita Albert Einstein experience

Juliana Folloni Fernandes, Fabio Rodrigues Kerbauy, Andreza Alice Feitosa Ribeiro, Jose Mauro Kutner, Luis Fernando Aranha Camargo, Adalberto Stape, [...]

DOI: 10.1590/S1679-45082011AO2007

ABSTRACT Objective: To report the experience of a tertiary care hospital with allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies. Methods: Seven pediatric patients with primary immunodeficiencies (severe combined immunodeficiency: n = 2; combined immunodeficiency: n = 1; chronic granulomatous disease: n = 1; hyper-IgM syndrome: n = 2; and IPEX syndrome: n = 1) who underwent eight hematopoietic stem cell transplants in a single center, from 2007 to 2010, were studied. Results: Two patients received transplants from […]

Multiple myeloma: five-year experience at a University Hospital

Juliana Todaro, Jandey Bigonha, Davimar Miranda Maciel Borducchi, Leandro Luongo Matos, Damila Cristina Trufelli, Suzane Martines Alves de Sales, [...]

DOI: 10.1590/S1679-45082011AO2006

ABSTRACT Objective: To present a descriptive analysis of patients diagnosed with multiple myeloma, correlating it with mortality. Methods: A retrospective study that analyzed consecutive patients diagnosed with multiple myeloma under follow-up at the Faculdade de Medicina do ABC from 2006 to 2010. Results: The median age was 58.5 years. Anemia was observed upon diagnosis in 87% of patients, hypercalcemia in 38%, and creatinine levels higher than 2 mg/dL in 19%. M protein was detected in 85.7%. The five-year survival rate […]

Correlation between flow cytometry and histologic findings: ten year experience in the investigation of lymphoproliferative diseases

Alanna Mara Pinheiro Sobreira Bezerra, Denise da Cunha Pasqualin, João Carlos de Campos Guerra, Marjorie Paris Colombini, Elvira Deolinda Rodrigues Pereira Velloso, Paulo Augusto Achucarro Silveira, [...]

DOI: 10.1590/S1679-45082011AO2027

ABSTRACT Objective: To demonstrate the advantages of correlating flow cytometry immunophenotyping with the pathology/ immunohistochemistry of lymph nodes or nodules in the diagnosis of lymphoproliferative diseases. Methods: A retrospective study was carried out of 157 biopsy or fine-needle aspiration lymph nodes/ nodule specimens taken from 142 patients, from 1999 and 2009. The specimens were simultaneously studied with fow cytometry and pathology at Hospital Israelita Albert Einstein. The specimens were prepared in hematoxylin/eosin, Giemsa, or monoclonal antibody stained slides for detecting […]

Incidence of alloimunization in sickle cell disease: experience of a center in São Paulo

Ricardo Helman, Rodolfo Delfini Cançado, Cristina Olivatto

DOI: 10.1590/S1679-45082011AO2003

ABSTRACT Objective: To identify the incidence of alloimmunization in sickle cell disease patients, as well as autoantibodies and the phenotypic profile of these patients for the following erythrocyte antigen groups: Rh, Kell, Kidd, Duffy and MNS. Methods: fifty-seven patients were evaluated during follow-up at the Anemia Outpatient Clinic of Irmandade da Santa Casa de São Paulo, where a search for irregular antibodies and phenotyping was carried out. Results: Patients’ median alloimmunization age in sickle cell disease was 25 years, and […]

Iron overload in Brazilian thalassemic patients

Reijane Alves de Assis, Fernando Uliana Kay, Laércio Alberto Rosemberg, Alexandre Henrique C. Parma, Cesar Higa Nomura, Sandra Regina Loggetto, [...]

DOI: 10.1590/S1679-45082011AO1897

ABSTRACT Objectives: To evaluate the use of magnetic resonance imaging in patients with β-thalassemia and to compare T2* magnetic resonance imaging results with serum ferritin levels and the redox active fraction of labile plasma iron. Methods: We have retrospectively evaluated 115 chronically transfused patients (65 women). We tested serum ferritin with chemiluminescence, fraction of labile plasma iron by cellular fluorescence and used T2* MRI to assess iron content in the heart, liver, and pancreas. Hepatic iron concentration was determined in […]

Prevalence of erythrocyte alloimmunization in polytransfused patients

Roberto de Oliveira Cruz, Mariza Aparecida Mota, Fabiana Mendes Conti, Ricardo Antônio d'Almeida Pereira, Jose Mauro Kutner, Maria Giselda Aravechia, [...]

DOI: 10.1590/S1679-45082011AO1777

ABSTRACT Objective: To determine the incidence and the rate of red blood cell alloimmunization in polytransfused patients. Methods: A polytransfused patient was defined as having received at least 6 units of red cell concentrates during a 3-month period. The records of all patients (n = 12,904) who had received red blood cell units were examined retrospectively by searching the computer database at Hospital Israelita Albert Einstein in São Paulo, Brazil, over a 6-year period, between 2003 and 2009. Results: During […]

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