533 results

Analysis of possible food/nutrient and drug interactions in hospitalized patients

Everton Moraes Lopes, Rumão Batista Nunes de Carvalho, Rivelilson Mendes de Freitas

DOI: 10.1590/s1679-45082010ao1672

ABSTRACTObjective:To evaluate the prescription in relation to the possible interactions between drugs and foods/nutrients in the diets of patients in the Hospital Regional Justino Luz in the municipality of Picos, Piauí, Brazil.Methods:The sample consisted of 60 medical records of patients admitted at the hospital. The records were analyzed according to the presence or absence of interactions between drugs and foods/nutrients of the prescribed diets.Results:Of the 82 drugs prescribed in all periods, there were 16 drugs (19.5%) with possible interaction with […]

Correlation between two physical activity programs in the gait of sedentary elderly subjects

Mariana Varkala Lanuez, Fernanda Varkala Lanuez, Eduardo Gunther Montero, Wilson Jacob Filho

DOI: 10.1590/s1679-45082010ao1585

ABSTRACTObjectives:To assess the effect of exercise on gait using two different programs: a group of aerobic exercises (Group A, n = 18) and a group of flexibility and balance exercises (Group B, n = 19).Methods:A casualized controlled study, in which each sample controlled itself, was undertaken. The sample comprised 37 male and female subjects, aged from 60 to 90 years, from the outpatient clinic of the Geriatrics Unit of Hospital das Clínicas of Faculdade de Medicina of Universidade de São […]

Biomarkers in Parkinson Disease: global gene expression analysis in peripheral blood from patients with and without mutations in PARK2 and PARK8

Patricia Maria de Carvalho Aguiar, Patricia Severino

DOI: 10.1590/s1679-45082010ao1674

ABSTRACTObjective:To evaluate the performance of gene expression analysis in the peripheral blood of Parkinson disease patients with different genetic profiles using microarray as a tool to identify possible diseases related biomarkers which could contribute to the elucidation of the pathological process, as well as be useful in diagnosis.Methods:Global gene expression analysis by means of DNA microarrays was performed in peripheral blood of Parkinson disease patients with previously identified mutations in PARK2 or PARK8 genes, Parkinson disease patients without known mutations […]

Impact of treadmill gait training with neuromuscular electrical stimulation on the urodynamic profile of patients with high cervical spinal cord injury

Carlos Arturo Levi D’Ancona, Alberto Clilclet, Lia Yumi Ikari, Renato Jesus Pedro, Walter da Silva Júnior

DOI: 10.1590/s1679-45082010ao1691

ABSTRACTObjective:To evaluate the impact of gait training with neuromuscular electrical stimulation on urodynamic parameters of patients with neurogenic bladder.Methods:Eight male quadriplegic patients with complete cervical injury level ranging from C4 to C7 comprised the study population. They underwent treadmill gait training with neuromuscular electrical stimulation for six months, only after having their quadriceps and tibialis anterior muscles stimulated for five months in order to support at least 50% of their body weight (pre-gait training). Urodynamic testing was performed before the […]

Frequency of peri-intraventricular hemorrhage and its associated factors in premature newborns

Evelyn Arrais Guzman, José Ricardo Dias Bertagnon, Yara Juliano

DOI: 10.1590/s1679-45082010ao1632

ABSTRACTObjective:To identify the frequency of intracranial hemorrhage and its associated factors in premature newborns.Methods:A cross-sectional study based on a survey of medical records of premature neonates submitted to transfontanellar ultrasound at a hospital located in a southern neighborhood of the city of São Paulo, in 2007.Results:A 50% rate of intracranial hemorrhage was found among premature newborns submitted to transfontanellar ultrasound, and 15.35% among all premature babies born in this hospital in 2007. The statistically significant factors associated to intracranial hemorrhage […]

Timing of initial surfactant treatment in very low birth weight newborns

Celso Moura Rebello, Luciene Ferreira do Amaral Nacif, Alice D´Agostini Deutsch, Ângela Tavares Paes

DOI: 10.1590/s1679-45082010ao1758

ABSTRACTObjective:To correlate the timing of treatment using exogenous surfactant with the main variables related to respiratory distress syndrome or prematurity.Methods:A historic cohort study between January 1, 2004 and June 30, 2007, including very low birth weight newborns (birth weight

Research knowledge in undergraduate school in Brazil: a comparison between medical and law students

Antonio José Souza Reis Filho, Bruno Bezerril Andrade, Vitor Rosa Ramos de Mendonça, Manoel Barral-Netto

DOI: 10.1590/s1679-45082010ao1702

ABSTRACTObjective:Exposure to science education during college may affect a student’s profile, and research experience may be associated with better professional performance. We hypothesized that the impact of research experience obtained during graduate study differs among professional curricula and among graduate courses.Methods:A validated multiple-choice questionnaire concerning scientific concepts was given to students in the first and fourth years of medical and law school at a public Brazilian educational institution.Results:Medical students participated more frequently in introductory scientific programs than law students, and […]

Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study

Rafael Kaliks, Camila Guerra, Auro Del Giglio

DOI: 10.1590/s1679-45082010ao1622

ABSTRACTObjective:To evaluate the efficacy and toxicity of the association of mitoxantrone and oral etoposide.Methods:Twelve consecutive patients with metastatic hormone-refractory prostate cancer were treated with mitoxantrone and oral etoposide. Toxicity, response rate and response duration were assessed.Results:Partial response was observed in two patients (response duration of seven and four months) and one patient had stable disease (during four months). Mitoxantrone and oral Etoposide were well tolerated and did not affect tolerability to subsequent chemotherapy.Conclusion:Mitoxantrone and oral etoposide association is an active […]

Impact of educational lectures on female adolescents’ knowledge about sexually transmitted diseases and cervical cancer in the city of Jundiaí, SP

João Bosco Ramos Borges, Marcus Vinícus Gonçalves Belintani, Patrícia Frodl Miranda, Ana Carolina Marchesini de Camargo, Renata Guarisi, Edna Marina Cappi Maia, [...]

DOI: 10.1590/s1679-45082010ao1544

ABSTRACTObjective:To evaluate the knowledge of adolescents living in Vila Ana and Morada das Vinhas region, in the city of Jundiaí, State of São Paulo, Brazil, on prevention and diagnosis of the main sexually transmitted diseases (STDs) and on cervical cancer, as well as the immediate impact of educational lectures.Methods:A prospective cross-sectional study was performed to assess the knowledge of a particular group of female adolescents about STDs and cervical cancer, by means of a questionnaire applied before and after educational […]

Adverse drug events leading to emergency department visits in elderly: the role of inappropriate prescription

José Marcelo Farfel, Tarso Augusto Duenhas Accorsi, Marcelo Franken, Sueli Pinto Doudement, Mariane Moran, Mauro Iervolino, [...]

DOI: 10.1590/s1679-45082010ao1473

ABSTRACTObjective:Adverse drug reactions are more incident among the elderly and are frequently associated to inappropriate prescription for this group. The objective of the current study was to investigate the incidence and the characteristics of emergency department visits, related to inappropriate prescription, at the Hospital Israelita Albert Einstein.Methods:Patients aged 60 years or older, admitted to the emergency department at Unidade Avançada Ibirapuera of Hospital Israelita Albert Einstein, were included in the study. Potentially inappropriate medication for the elderly was evaluated using […]

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