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Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide deficient rats

Carlos Arturo Levi D'Ancona, Fabíola Zakia Taufic Mónica, Ricardo Reges, David Cohen, Fabio Henrique da Silva, Gilberto De Nucci, [...]

DOI: 10.1590/S1679-45082010AO1789

ABSTRACT Objective: to evaluate the protective effects of BAY 41-2272, a soluble guanylate cyclase activator, on changes in cystometric parameters in rats deficient in nitric oxide (NO). Methods: Rats were divided into the following groups: (a) control; (b) DMSO; (c) L-NAME; (d) BAY 41-2272 alone; (e) L-NAME + BAY 41-2272. The NO synthase blocker L-NAME (20 mg/rat/day) was given in drinking water concomitantly or not with BAY 41-2272 (10 mg/kg/day, given by gavage). Results: Chronic L-NAME treatment markedly increased the […]