Highlights ■ TSO500 showed 93.39% sensitivity and high concordance with FoundationOne. ■ Comprehensive Genomic Profiling of 454 tumors revealed the genomic landscape of 57 cancer types. ■ Variants of uncertain significance comprised 57.9% of all genomic events, highlighting challenges in precision oncology. ■ Gene fusions occurred in 13% of cases, with 45.5% classified as variants of uncertain significance. ABSTRACT Background: Precision medicine has transformed cancer management by tailoring treatments to the molecular characteristics of a patient’s tumor. Comprehensive Genomic Profiling […]