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Influence of gastric emptying on the control of postprandial glycemia: physiology and therapeutic implications

Marcos Antonio Tambascia, Domingos Augusto Cherino Malerbi, Freddy Goldberg Eliaschewitz

DOI: 10.1590/S1679-45082014RB2862

The maintenance of glucose homeostasis is complex and involves, besides the secretion and action of insulin and glucagon, a hormonal and neural mechanism, regulating the rate of gastric emptying. This mechanism depends on extrinsic and intrinsic factors. Glucagon-like peptide-1 secretion regulates the speed of gastric emptying, contributing to the control of postprandial glycemia. The pharmacodynamic characteristics of various agents of this class can explain the effects more relevant in fasting or postprandial glucose, and can thus guide the individualized treatment, […]